99113-89-0

Basic information

• Product Name: 5-(2 5-DICHLOROPHENYL)FURFURAL 96
• Synonyms: 5-(2 5-DICHLOROPHENYL)FURFURAL 96;2-Furancarboxaldehyde,5-(2,5-dichlorophenyl)-;5-(2,5-Dichlorophenyl)furfural 96%;5-(2,5-dichlorophenyl)-2-furancarboxaldehyde
• CAS NO: 99113-89-0
• Molecular Formula: C₁₁H₆Cl₂O₂
• Molecular Weight: 241.072
• Product Categories: API intermediates;Building Blocks;Furans;FuransHeterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 99113-89-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 97-101 °C(lit.)
• Boiling Point: 361°Cat760mmHg
• Flash Point: 172.2°C
• Appearance: /
• Density: 1.392g/cm³
• Vapor Pressure: 2.13E-05mmHg at 25°C
• Refractive Index: 1.605
• CAS DataBase Reference: 5-(2 5-DICHLOROPHENYL)FURFURAL 96(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2 5-DICHLOROPHENYL)FURFURAL 96(99113-89-0)
• EPA Substance Registry System: 5-(2 5-DICHLOROPHENYL)FURFURAL 96(99113-89-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 99113-89-0(Hazardous Substances Data)

Usage

General Description

5-(2,5-Dichlorophenyl)furfural 96 is a chemical compound with the molecular formula C10H6Cl2O2. It is a yellow crystalline solid that is commonly used in the production of pharmaceuticals and agrochemicals. 5-(2 5-DICHLOROPHENYL)FURFURAL 96 is also used as a building block in the synthesis of various organic compounds. It is known for its strong aromatic odor and is considered to be hazardous if not handled properly. 5-(2,5-Dichlorophenyl)furfural 96 is a versatile chemical that has many industrial applications and is an important component in the manufacturing of various products.

InChI:InChI=1/C11H6Cl2O2/c12-7-1-3-10(13)9(5-7)11-4-2-8(6-14)15-11/h1-6H

Upstream product

• 27329-70-0 5-formylfurane-2-boronic acid 
• 29682-41-5 2,5-dichloroiodobenzene 
• 98-01-1 furfural 
• 95-82-9 2,5 dichloroaniline 
• 50-79-3 2,5-dichlorobenzoic acid 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 135145-90-3 2,5-dichlorobenzeneboronic acid 
• 106-46-7 para-dichlorobenzene 

Downstream Products

• 1333376-18-3 C₁₉H₁₇Cl₂NO 
• 303093-78-9 diethyl 2,6-dimethyl-4-[5'-(2'',5''-dichlorophenyl)furan-2'-yl]-1,4-dihydropyridine-3,5-dicarboxylate 
• 691388-62-2 C₁₆H₁₀Cl₂N₂OS 
• 1427538-15-5 2-((5Z)-5-{[5-(2,5-dichlorophenyl)-2-furyl]methylene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)butanoic acid 

Relevant articles and documents

5-Aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety as potential PTP1B inhibitors

Two series of 5-aryl-furan derivatives bearing a phenylalanine- or isoleucine-derived rhodanine moiety were identified as competitive protein tyrosine phosphatase 1B (PTP1B) inhibitors. Among the compounds studied, 5g was found to have the best PTP1B inhibitory potency (IC50 = 2.66 ± 0.16 μM) and the best cell division cycle 25 homolog B (CDC25B) inhibitory potency (IC50 = 0.25 ± 0.02 μM). Enzymatic data together with molecular modeling results demonstrated that the introduction of a sec-butyl group at the 2-position of the carboxyl group remarkably improved the PTP1B inhibitory activity.

5-Aryl-2-furaldehydes in the synthesis of tetrahydropyrimidinones by Biginelli reaction

5-Aryl-2-furaldehydes, obtained by furfural arylation with arenediazonium salts, react with ethyl acetoacetate or acetylacetone and (thio)- urea in the presence of FeCl3·6H2O as a catalyst. A series of ethyl 4-(5-aryl-2-furyl)-6-methyl-2-oxo(thioxo)-1,2,3,4-tetrahydropyrimidine- 5-carboxylates was obtained.

Synthesis and antibacterial evaluation of furan derivatives bearing a rhodanine moiety

Two series of furan derivatives bearing a rhodanine moiety (4a-l and 5a-l) have been synthesized, characterized, and evaluated for their antibacterial activity. The majority of these compounds showed potent levels of inhibitory activity against a variety of different Gram-positive bacteria, including multidrug-resistant clinical isolates, with minimum inhibitory concentration (MIC) values in the range of 2-16 μg/mL. In particular, compound 4l was found to be the most potent of the synthesized compounds against the multidrug-resistant strains, with a MIC value of 2 or 4 μg/mL. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at 64 μg/mL. An examination of the cytotoxicities of these agents revealed that they displayed low levels of toxicity toward HeLa cells. All of the compounds synthesized in the current paper were characterized by 1H and 13C NMR, infrared, and mass spectroscopy. Graphical Abstract: Two novel series of furan derivatives bearing a rhodanine moiety were synthesized, and evaluated for their antibacterial activity. Compounds 4l and 5a presented high potency against several multidrug-resistant clinical isolates.[Figure not available: see fulltext.]