99126-64-4

Basic information

• Product Name: MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER
• Synonyms: METHOXYPOLYETHYLENE GLYCOL 5,000 MALEIMIDE;O-(2-MALEIMIDOETHYL)-O'-METHYLPOLYETHYLENE GLYCOL 5'000;PEG-MALEIMIDE;MONO-METHYL POLYETHYLENE GLYCOL 5,000 2-MALEIMIDO-ETHYL ETHER;MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER;O-(2-MALEIMIDOETHYL)-O'-METHYLPOLY-ETHYLENE GLYCOL 5000 90+%;PEG-maleimide, mono-Methyl polyethylene glycol 5μ000 2-maleimidoethyl ether;MeO-PEG-C2H4-Mal
• CAS NO: 99126-64-4
• Molecular Formula: (C2H4O)n.C7H9NO3
• Molecular Weight: 0
• Product Categories: Maleimide;Materials Science;Monofunctional PEGs;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Polymers;Polydispersed PEG;PEG
• Mol File: 99126-64-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 48-52 °C
• Flash Point: >110 °C
• Appearance: /
• Storage Temp.: −20°C
• CAS DataBase Reference: MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER(99126-64-4)
• EPA Substance Registry System: MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER(99126-64-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3-10-23
• Hazardous Substances Data: 99126-64-4(Hazardous Substances Data)

Usage

Description

MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER, also known as Methoxypolyethylene glycol maleimide (MeO-PEG-Mal), is a maleimide-functionalized poly(ethylene glycol) polymer with a molecular weight of 5,000. It is a water-soluble reagent that can be used for the conjugation of thiol-containing biomolecules, APIs, or targeting ligands.

Uses

Used in Bioconjugation:
MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER is used as a bioconjugation reagent for the rapid and efficient attachment of thiol-containing biomolecules, APIs, or targeting ligands. The maleimide group in the polymer reacts with thiols to form stable thioether linkages, allowing for the formation of stable conjugates.
Used in Protein PEGylation:
In the pharmaceutical industry, MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER is used as a protein pegylation reagent. PEGylation is the process of covalently attaching polyethylene glycol (PEG) polymer chains to proteins, which can improve their stability, solubility, and circulation time in the body, as well as reduce their immunogenicity.
Used in Drug Delivery Systems:
In drug delivery applications, MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER can be used to modify drug molecules or drug delivery systems, such as nanoparticles or liposomes, to improve their stability, solubility, and targeting capabilities. The PEGylation of drug molecules or drug delivery systems can also help to reduce their clearance rate and improve their therapeutic efficacy.
Used in Immobilization:
MONO-METHYL POLYETHYLENE GLYCOL 5'000 2-MALEIMIDOETHYL ETHER is also used for the immobilization of proteins or other biomolecules on various surfaces, such as sensors, microarrays, or chromatography columns. The maleimide group can react with thiol-containing ligands or spacers, allowing for the covalent attachment of biomolecules to the surface.