99149-83-4

Basic information

• Product Name: perindopril
• Synonyms: 1H-Indole-2-carboxylic acid, 1-((2S)-2-(((1S)-1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, (2S,3as,7as)-
• CAS NO: 99149-83-4
• Molecular Formula: C19H32N2O5
• Molecular Weight: 368.46778
• Mol File: 99149-83-4.mol
• Article Data: 35

Chemical Properties

• Appearance: /
• CAS DataBase Reference: perindopril(CAS DataBase Reference)
• NIST Chemistry Reference: perindopril(99149-83-4)
• EPA Substance Registry System: perindopril(99149-83-4)

Safety Data

• Hazardous Substances Data: 99149-83-4(Hazardous Substances Data)

Upstream product

• 866430-96-8 (2S,3aS,7aS)-1-{2-[1-ethoxycarbonyl-(S)-butylamino]-(S)-propionyl}-octahydroindole-2-carboxylic acid p-nitrobenzylic ester 
• 1477-50-5 Indole-2-carboxylic acid 
• 3770-50-1 2-carbethoxyindole 
• 4792-54-5 ethyl pyruvate phenylhydrazone 
• 100-63-0 phenylhydrazine 
• 488097-90-1 Ethyl (2S)-2-[(4S)-4-methyl-2,5-dioxo-1,3-oxazolidin-3-yl]pentanoate 
• 107045-53-4 (2S,3aS,7aS)-1-(benzyloxycarbonyl)octahydro-1H-indole-2-carboxylic acid 
• 23358-62-5 (S) norvaline ethyl ester hydrochloride 
• 79815-20-6 (S)-indoline-2-carboxylic acid 
• 80875-98-5 (2S,3aS,7aS)-perhydroindole-2-carboxylic acid 
• 79854-42-5 Ethyl (S)-indoline-2-carboxylate hydrochloride 
• 82864-25-3 ethyl (2S,3aS,7aS)-octahydro-1H-indole-2-carboxylate hydrochloride 
• 50461-74-0 ethyl 2-oxovalerate 
• 80876-00-2 (2α,3aβ,7aβ)-octahydro-1H-indole-2-carboxylic acid tert-butyl ester 

Relevant articles and documents

Method for preparing perindopril despinner and intermediate thereof

The invention discloses a method for preparing perindopril despinner and an intermediate thereof. The method comprises the following steps: halogenating N-propionyl indole-2-carboxylic acid under theaction of a halogenation reagent so as to obtain a halogenation product, and further carrying out amine substitution and catalytic hydrogenation reduction on the obtained halogenation product, therebyobtaining the perindopril despinner. Compared with the prior art, the method is cheap and easy in reaction raw material, has a total yield as high as 64%, is high in product purity and is applicableto industrial production.

PROCESS FOR THE PREPARATION OF THE L-ARGININE SALT OF PERINDOPRIL

Process for the preparation of the compound of formula (I):

PROCESS FOR THE PREPARATION OF PERINDOPRIL ERBUMINE SALT AND NOVEL POLYMORPH (S) THEREOF

A single pot process for the preparation of perindopril erbumine salt according to which condensation of (2S, 3aS, 7aS)-octahydroindole-2-carboxylic acid benzyl ester para toluene sulfonate with N-((S-)-ethoxy carbonyl -1-ethyl-(S)-alanine, catalytic hydrogenation of benzyl ester of (2S, 3aS, 7aS)-1-{2-[1-(ethoxycarbonyl)-(S)-butylamino]-(S)propionyl}- octahydro-indole-2-carboxylate and conversion of (2S,3aS, 7aS)-1-{2-[1-ethoxycarbonyl)_(S)-butylamino]-(S)-propionyl}octahydroindole-2-carboxylic acid to its perindopril erbumine salt are carried out in a single pot using a single solvent such as isopropyl acetate to obtain perindopril erbumine salt of very high purity. Also a novel polymorph S of perindopril erbumine having X-ray diffraction peaks of 9.10, 14.64, 15.37, 16.58, 17.39, 19.99, 20.62, 21.50, 22.15, 22.60, 24.20, 27.55 ± 0.2 at 2Θ values. Also processes for preparing the novel polymorph S.