99169-99-0

Basic information

• Product Name: N,N-DIMETHYLINDOLINE-5-SULFONAMIDE
• Synonyms: 2,3-DIHYDRO-N,N-DIMETHYL-5-(1H)-INDOLESULFONAMIDE;2,3-DIHYDRO-N,N-DIMETHYL-5-(1H)-INDOLESULPHONAMIDE;AKOS BBS-00002771;BUTTPARK 120\07-100;TIMTEC-BB SBB010224;N,N-DIMETHYLINDOLINE-5-SULFONAMIDE;N,N-Dimethylindoline-5-sulphonamide;5-(N,N-Dimethylsulphamoyl)indoline, 2,3-Dihydro-N,N-dimethyl-1H-indole-5-sulphonamide, 2,3-Dihydro-5-(N,N-dimethylsulphamoyl)-1H-indole
• CAS NO: 99169-99-0
• Molecular Formula: C₁₀H₁₄N₂O₂S
• Molecular Weight: 226.3
• Mol File: 99169-99-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 109-111
• Boiling Point: 389.8 °C at 760 mmHg
• Flash Point: 189.5 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 2.78E-06mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: N,N-DIMETHYLINDOLINE-5-SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYLINDOLINE-5-SULFONAMIDE(99169-99-0)
• EPA Substance Registry System: N,N-DIMETHYLINDOLINE-5-SULFONAMIDE(99169-99-0)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 99169-99-0(Hazardous Substances Data)

Usage

General Description

N,N-Dimethylindoline-5-sulfonamide is a synthetic compound that belongs to the class of organic compounds known as indolines. Indolines are compounds containing an indoline moiety, which is structurally characterized by a benzene ring fused to a 2-aminotetrahydrofuran. N,N-Dimethylindoline-5-sulfonamide is specifically characterized by the presence of sulfonamide functional groups, which consist of sulfur, oxygen, and nitrogen atoms. Sulfonamides are known for their biological activity and are often used in medicinal chemistry. However, information regarding the specific properties and potential applications of N,N-Dimethylindoline-5-sulfonamide is limited.

InChI:InChI=1/C10H14N2O2S/c1-12(2)15(13,14)9-3-4-10-8(7-9)5-6-11-10/h3-4,7,11H,5-6H2,1-2H3

Upstream product

• 90918-44-8 N,N-dimethylindole-5-sulfonamide 
• 79679-16-6 5-chlorosulfonylindoline-1-carboxaldehyde 
• 2861-59-8 N-formylindoline 
• 496-15-1 1-indoline 
• 155110-46-6 N-Formyl-5-(dimethylsulfomoyl)indoline 

Downstream Products

• 1026920-15-9 2-[3,6-Bis-(5-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonic acid 
• 1026167-92-9 2-[3,6-Bis-(5-dimethylsulfamoyl-2,3-dihydro-indol-1-yl)-9H-xanthen-9-yl]-benzenesulfonyl chloride 

Relevant articles and documents

Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships

Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.