99179-98-3

Basic information

• Product Name: 2-Bromo-4-ethyl-1-methoxybenzene
• Synonyms: 2-Bromo-4-ethyl-1-methoxybenzene;2-Bromo-4-ethylanisole
• CAS NO: 99179-98-3
• Molecular Formula: C₉H₁₁BrO
• Molecular Weight: 215.08704
• Mol File: 99179-98-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Bromo-4-ethyl-1-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-ethyl-1-methoxybenzene(99179-98-3)
• EPA Substance Registry System: 2-Bromo-4-ethyl-1-methoxybenzene(99179-98-3)

Safety Data

• Hazardous Substances Data: 99179-98-3(Hazardous Substances Data)

Usage

Uses

2-Bromo-4-ethylanisole is a useful synthesis research reagent.

Upstream product

• 1515-95-3 p-ethylanisole 

Downstream Products

• 108295-00-7 (5-ethyl-2-methoxy-phenyl)-pyridin-2-yl-methanone 
• 94670-27-6 1-(3-bromo-α-methyl-4-methoxyphenyl)ethyl methyl ether 
• 847345-26-0 (5-ethyl-biphenyl-2-yl)-methyl ether 
• 847345-29-3 2-(5-ethyl-2-methoxy-phenyl)-pyrrole-1-carboxylic acid tertbutyl ester 
• 108294-99-1 1-(5-ethyl-2-hydroxyphenyl)-1-(4-pyridyl)methanone 
• 108295-02-9 4-(5-ethyl-2-methoxybenzoyl)pyridine N-oxide 
• 108294-98-0 (5-ethyl-2-hydroxy-phenyl)-pyridin-2-yl-methanone 

Relevant articles and documents

Bis-selenonium Cations as Bidentate Chalcogen Bond Donors in Catalysis

Lewis acids are frequently employed in catalysis but they often suffer from high moisture sensitivity. In many reactions, catalysts are deactivated because of the problem that strong Lewis acids also bond to the products. In this research, hydrolytically stable bidentate Lewis acid catalysts derived from selenonium dicationic centers have been developed. The bis-selenonium catalysts are employed in the activation of imine and carbonyl groups in various transformations with good yields and selectivity. Lewis acidity of the bis-selenonium salts was found to be stronger than that of the monoselenonium systems, attributed to the synergistic effect of the two cationic selenonium centers. In addition, the bis-selenonium catalysts are not inhibited by strong bases or moisture.

Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics

Halogenated aromatic compounds are the cores of many pharmaceutical, agricultural and chemical products but they are commonly prepared using electrophilic halogenation reactions in non-green chlorinated solvents under harsh conditions. A separate problem happens in the aromatic halogenation of thioarenes because they readily undergo oxidative side-reactions. Herein we report an environmentally benign electrophilic bromination of aromatics using an indole-catalytic protocol, which is suitable for a wide range of substrates including thioarenes.

Bromination of Anisoles Using N-Bromophthalimide: A Synthetic and Kinetic Approach

N-Bromophthalimide (NBP)-triggered bromination of aromatic compounds has been studied in the presence of aqueous acetic acid. Reaction Kinetics indicated first order in [NBP] and zero order in [Anisole]. The reactions afforded very good yields of corresponding bromo derivatives under kinetic conditions. The mechanism of the reaction is explained through the formation of acetyl hypobromite due to the interaction of NBP and acetic acid, which in turn reacts with anisole to afford a bromo derivative of anisole.