993-48-6Relevant articles and documents
The Influence of Hydrophobic Solvation on the Alkaline Hydrolysis of Ethyl Esters of Polar Substituted 2-Methylpropionic Acids in Water
Schmeer, G.,Riembauer, S.,Barthel, J.
, p. 1175 - 1190 (2007/10/02)
The rate constants of the alkaline hydrolysis of 2-methylpropionic acid ethyl ester, α-hydroxy, α-bromo, α-cyano, and α-nitro-2-methylpropionic acid ethyl ester have been measured in water between 5 deg C and 45 deg C with the help of an appropiate conductance bridge developed in our laboratory.The influence of the polar substituents on the rate constant, a powerful probe for discussing two-particle interactions in solutions, is characterized by an intramolecular structure parameter of the activated complex and a dielectric parameter of its surroundings.The dependence of the reaction rate on the structure parameter is compared to that of substituted acetic acid derivatives.The smaller dielectric parameter of 2-methylpropionic acid esters reveals the increasing hydrophobic solvation in comparison to acetic acid derivatives.