99334-20-0

Basic information

• Product Name: methyl 3-(4-fluorophenyl)glycidate
• Synonyms: methyl 3-(4-fluorophenyl)glycidate
• CAS NO: 99334-20-0
• Molecular Weight: 196.178
• Mol File: 99334-20-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 3-(4-fluorophenyl)glycidate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(4-fluorophenyl)glycidate(99334-20-0)
• EPA Substance Registry System: methyl 3-(4-fluorophenyl)glycidate(99334-20-0)

Safety Data

• Hazardous Substances Data: 99334-20-0(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 96-34-4 methyl chloroacetate 
• 116-54-1 dichloroacetic acid methyl ester 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 

Downstream Products

• 139618-72-7 Methyl trans-3-(4-fluorophenyl)aziridine-2-carboxylate 
• 139618-92-1 (4R,5R)-4-(4-Fluoro-phenyl)-2,2,2-triphenyl-2λ⁵-[1,3,2]oxazaphospholidine-5-carboxylic acid methyl ester 
• 85589-65-7 3-(4-fluorophenyl)pyridine 
• 1736-67-0 4-fluorophenylacetaldehyde 

Relevant articles and documents

Dynamic kinetic asymmetric transformations of β-halo-α-keto esters by N,N′-dioxide/Ni(II)-catalyzed carbonyl-ene reaction

Dynamic kinetic asymmetric transformations of racemic β-halo-α-keto esters through carbonyl-ene reaction were realized using a chiral N,N′-dioxide-nickel(ii) complex, giving the corresponding β-halo-α-hydroxy esters containing two vicinal chiral tri- and tetrasubstituted carbon centers in good yields and dr with excellent ee values without the use of extra bases. Meanwhile, a proposed reaction mechanism was presented according to the configuration of the product.

Enantiopure trans -3-arylaziridine-2-carboxamides: Preparation by bacterial hydrolysis and ring-openings toward enantiopure, unnatural D -α-amino acids

Several racemic trans-3-arylaziridine-2-carboxamides were prepared and then resolved by Rhodococcus rhodochrous IFO 15564-catalyzed hydrolysis. The resulting enantiopure (2R,3S)-3-arylaziridine-2-carboxamides are adequate substrates to undergo fully stereoselective nucleophilic ring-openings at the C-3 ring position to finally yield enantiopure, unnatural d-α- aminocarboxylic acids. Experimental evidence is provided that suggests the fate of the (2S,3R)-3-arylaziridine-2-carboxylic acids concomitantly formed during the resolution processes. In this context, the similar bacterial resolution of racemic 1-arylaziridine-2-carboxamides and -carbonitriles, previously investigated by our research group, has been partially re-examined.

An improved procedure for the epoxidation of methyl cinnamate derivatives and production of acid sensitive epoxides

By using a biphasic epoxidation system, unreactive methyl cinnamate derivatives were epoxidized at higher rates, and epoxides that decomposed in the presence of m-chlorobenzoic acid (mCBA) to diol ester opening products under standard conditions were obtained in fair to excellent yields.