99418-37-8

Basic information

• Product Name: 4-chloro-N,N-dimethyl-5-nitro-2-pyrimidinamine
• CAS NO: 99418-37-8
• Molecular Weight: 202.6
• Mol File: 99418-37-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-chloro-N,N-dimethyl-5-nitro-2-pyrimidinamine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-N,N-dimethyl-5-nitro-2-pyrimidinamine(99418-37-8)
• EPA Substance Registry System: 4-chloro-N,N-dimethyl-5-nitro-2-pyrimidinamine(99418-37-8)

Safety Data

• Hazardous Substances Data: 99418-37-8(Hazardous Substances Data)

Upstream product

• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 49845-33-2 2,4-Dichloro-5-nitropyrimidine 

Downstream Products

• 45939-75-1 N²,N²-dimethyl-pyrimidine-2,4,5-triyltriamine 
• 5096-84-4 N²,N²-dimethyl-5-nitro-pyrimidine-2,4-diamine 

Relevant articles and documents

Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles

The SNAr reaction of 2,4-dichloropyrimidines, further substituted with an electron-withdrawing substituent at C-5, has selectivity for substitution at C-4. Here we report that tertiary amine nucleophiles show excellent C-2 selectivity. In situ N-dealkylation of an intermediate gives the product that formally corresponds to the reaction of a secondary amine nucleophile at C-2. This reaction is practical (fast under simple reaction conditions, with good generality for tertiary amine structure and moderate to excellent yields) and significantly expands access to pyrimidine structures.