99440-98-9Relevant articles and documents
Novel hypervalent iodine catalyzed synthesis of α-sulfonoxy ketones: Biological activity and molecular docking studies
Atmaca, Ufuk,Alp, Cemalettin,Akincioglu, Hulya,Karaman, Halide Sedef,Gül?in, ?lhami,?elik, Murat
, (2021/05/06)
The novel di((camphorsulfonyl)oxy)iodo]benzene (DCIB) was synthesized from [Bis(trifluoroacetoxy)iodo]benzene in the mild conditions. The α-sulfonoxylation of various ketones with novel hypervalent iodine was reported in excellent yield. α-Hydroxyketones
Ligustrazine-fused cyclic compound and medicine composition thereof, as well as application in medicine thereof
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, (2017/07/21)
The invention discloses a ligustrazine-fused cyclic compound and a medicine composition thereof and application in a medicine. The ligustrazine-fused cyclic compound has the following structural general formula I: as shown in the specification. The medicine composition is a medicinal active component for the ligustrazine-fused cyclic compound and a pharmaceutically acceptable carrier, an excipient, a diluent, an adjuvant, a medium or a combination thereof; the ligustrazine-fused cyclic compound and the medicine composition can be used for preventing or treating cardiovascular and cerebrovascular diseases, digestive system diseases, respiratory diseases, the alzheimer's disease, kidney diseases and complications of the above-mentioned diseases due to thrombus and excessive free radicals. The ligustrazine-fused cyclic compound disclosed by the invention has an extremely good inhibition effect on in vitro ADP (adenosine diphosphate)-induced platelet aggregation; meanwhile, compared with the pharmacokinetic property of ligustrazine serving as a female parent, the pharmacokinetic property of the ligustrazine-fused cyclic compound in the body of a rat is obviously improved.
An efficient method for selective oxidation of 1,2-diols in water catalyzed by Me2SnCl2
William, Julius M.,Kuriyama, Masami,Onomura, Osamu
, p. 19247 - 19250 (2013/10/22)
Dimethyltin(iv)dichloride-catalyzed selective oxidation of 1,2-diols in water was achieved using dibromoisocyanuric acid (DBI) or Br2 as oxidants. The catalyst activates the 1,2-diol moiety through the formation of stannylene acetal in addition to enhancing selectivity. Various cyclic and acyclic 1,2-diol substrates have been selectively oxidized affording α-hydroxyketones in good to excellent yields. This method is safe and simple in operation.