99505-03-0Relevant articles and documents
Substituted indole compounds having NOS inhibitory activity
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Page/Page column 43, (2010/11/24)
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The NOS inhibitors of the invention, alone or in combination w
INDOLE DERIVATIVES
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, (2008/06/13)
Compounds of the formula STR1 wherein Z is STR2 R 1 is STR3 X is O, NH, or S; A, B, D, E, and F are each independently C, N, O, or S; wherein the remaining variables are defined in the specification, and the pharmaceutically acceptable salts thereof. Thes
A simple synthesis of 5-amino-3-(2-dimethylaminoethyl)indole [5-amino-N,N-dimethyltryptamine]
Macor,Post,Ryan
, p. 65 - 72 (2007/10/02)
A short (three step) synthesis of 5-amino-3-(2-dimethylaminoethyl)indole [5-amino-N,N-dimethyltryptamine, 4] from commercially available starting materials is presented. Reaction of 5-nitroindole with oxalyl chloride followed by dimethylamine afforded N,N-dimethyl 5-nitroindole-3-glyoxamide (1), which was reduced by diborane to 5-nitro-3-(2-dimethylaminoethyl)indole (3). Catalytic reduction of (3) afforded the title compound in 19% overall yield from 5-nitroindole.