99520-05-5

Basic information

• Product Name: 2,6-Dichloro-4-Methylbenzoic acid
• Synonyms: 2,6-Dichloro-4-Methylbenzoic acid
• CAS NO: 99520-05-5
• Molecular Formula: C₈H₆Cl₂O₂
• Molecular Weight: 205.03804
• Mol File: 99520-05-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 329.0±37.0 °C(Predicted)
• Appearance: /
• Density: 1.442±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.91±0.25(Predicted)
• CAS DataBase Reference: 2,6-Dichloro-4-Methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-Dichloro-4-Methylbenzoic acid(99520-05-5)
• EPA Substance Registry System: 2,6-Dichloro-4-Methylbenzoic acid(99520-05-5)

Safety Data

• Hazardous Substances Data: 99520-05-5(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-Methylbenzoic acid is a chemical compound with the molecular formula C8H6Cl2O2. It is a white to off-white solid that is sparingly soluble in water. 2,6-Dichloro-4-Methylbenzoic acid is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of dyes and pigments. 2,6-Dichloro-4-Methylbenzoic acid is known for its strong acidic properties and is often used as a catalyst in organic synthesis reactions. Additionally, it is widely used in the study and development of new compounds for various industries.

Upstream product

• 94-08-6 4-methylbenzoic acid ethyl ester 
• 99500-35-3 ethyl 2-chloro-4-methylbenzoate 
• 124-38-9 carbon dioxide 
• 25186-47-4 3,5-dichlorotoluene 

Downstream Products

• 99508-23-3 2',6',4''-trichloro-4'-methylbenzophenone 
• 25186-47-4 3,5-dichlorotoluene 
• 1098620-10-0 methyl 2,6-dichloro-4-aldehyde benzoate 
• 135340-70-4 5-Amino-1-[3,5-dichloro-4-(4-trichlorovinyl-benzoyl)-benzyl]-1H-[1,2,3]triazole-4-carboxylic acid amide 
• 135340-72-6 4-[4-(5-Amino-4-carbamoyl-[1,2,3]triazol-1-ylmethyl)-2,6-dichloro-benzoyl]-benzoic acid methyl ester 
• 135340-71-5 5-Amino-1-[3,5-dichloro-4-(4-cyano-benzoyl)-benzyl]-1H-[1,2,3]triazole-4-carboxylic acid amide 
• 135340-73-7 5-amino-1-[4-(3,4-dichlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide 
• 135340-77-1 5-Amino-3-[3,5-dichloro-4-(4-chloro-benzoyl)-benzyl]-3H-[1,2,3]triazole-4-carboxylic acid amide 
• 99880-60-1 5-Amino-1-(4-benzoyl-3,5-dichlorobenzyl)-1,2,3-triazole-4-carboxamide 
• 135340-64-6 (4-Azidomethyl-2,6-dichloro-phenyl)-(3,4-dichloro-phenyl)-methanone 
• 135340-54-4 (4-Bromomethyl-2,6-dichloro-phenyl)-(4-trichlorovinyl-phenyl)-methanone 
• 135340-63-5 4-(4-Azidomethyl-2,6-dichloro-benzoyl)-benzonitrile 
• 135340-56-6 4-(4-Bromomethyl-2,6-dichloro-benzoyl)-benzoic acid methyl ester 
• 135340-42-0 (2,6-Dichloro-4-methyl-phenyl)-(4-trichlorovinyl-phenyl)-methanone 

Relevant articles and documents

PYRAZOLE AMIDE DERIVATIVE

The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Benzylated 1,2,3-triazoles as anticoccidiostats

Substituted 5-amino-4-carbamoyl-1,2,3-triazoles 3a-w were prepared by two synthetic schemes and evaluated in vivo for anticoccidial activity. Both schemes proceeded by brominating appropriately substituted toluenes 4a-s,v to 5a-s,v. In Scheme I, the brominated benzyl analogues 5 were converted to the corresponding benzyl azides 6, which were treated with cyanoacetamide to yield 1-substituted-5-amino-4-carbamoyl-1,2,3-triazoles 3. In Scheme II, the benzyl halides 5 were employed to alkylate the sodium salt of 5-amino-4-carbamoyl-1,2,3-triazole (7). Preliminary screening data against Eimeria acervulina and E. tenella in chickens suggested structural requirements for maximizing activity. Further evaluation against a relatively resistant series of eight Eimeria field isolates revealed L-651,582 (3a) to be a highly effective coccidiostat. However, unacceptable tissue residues precluded further development. Mechanistic studies on this series of 5-amino-4-carbamoyl-1,2,3-triazoles and, in particular, on L-651,582 (3a) revealed that its mode of action does not involve inhibition of IMP dehydrogenase, but probably interferes with host cell calcium entry. In addition, L-651,582 has been found to have antiproliferative activity in several disease models and was recently reported to possess antimetastatic activity in a model of ovarian cancer progression.

5-amino or substituted amino 1,2,3-triazoles

Novel 5-amino or substituted amino 1,2,3-triazoles are disclosed as having anticoccidial activity. The compounds are useful for controlling coccidiosis when administered in minor quantities to animals, in particular to poultry, usually in admixture with a