99566-52-6

Basic information

• Product Name: 1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanone
• Synonyms: (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)ethanone;(S)-1-(2,2-dimethyl-1,3-dioxolan-4-yl)ethan-1-one
• CAS NO: 99566-52-6
• Molecular Formula: C₇H₁₂O₃
• Molecular Weight: 144.1684
• Mol File: 99566-52-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 185.9°C at 760 mmHg
• Flash Point: 56.3°C
• Density: 1.026g/cm³
• Vapor Pressure: 0.681mmHg at 25°C
• Refractive Index: 1.42
• CAS DataBase Reference: 1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanone(99566-52-6)
• EPA Substance Registry System: 1-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanone(99566-52-6)

Safety Data

• Hazardous Substances Data: 99566-52-6(Hazardous Substances Data)

Upstream product

• 75-16-1 methylmagnesium bromide 
• 117770-23-7 (S)-(+)-N,N-dimethyl-2,3-O-isopropylideneglyceramide 
• 77-76-9 2,2-dimethoxy-propane 
• 102045-96-5 2,3-O-isopropylidene-L-glyceric acid 
• 917-54-4 methyllithium 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 22323-80-4 (4S)-2,2-dimethyl-[1,3]dioxolane-4-carbaldehyde 
• 325970-14-7 (2S)-1,2,3-butanetriol-1,2-acetonide 
• 676-58-4 methylmagnesium chloride 
• 133481-14-8 (2S)-2,3-O-isopropylidene-N-methoxy-N-methylpropanamide 
• 99566-51-5 (E)-(R)-3-methyl-4-(3-phenoxyphenyl)-3-buten-1,2-diol acetonide 

Downstream Products

• 1204707-84-5 (1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-N-phenylmethyl-ethanamine 
• 1204707-75-4 (1R)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-N-[(1R)-1-phenylethyl]ethanamine 

Relevant articles and documents

An expedient synthesis of (R)-(+)-umbelactone

The synthesis of the naturally occurring 2(5H)-furanone (R)-(+)-umbelactone 1 in five steps and 26.2% overall yield from (2S)-2,3-dihydroxy-(2,3-O-isopropylidene)propanoic acid 2 is described.

NOVEL COMPOUND 395

A compound of formula (1) and pharmaceutically acceptable salts thereof for use in the treatment of chemokine mediated diseases and conditions.

A route to homochiral (S)-O-methyl mandelic acid and related α-alkoxy carboxylic acids from isopropylidene glycerol

An improved synthesis of the useful ketones 7 is described. These ketones are then further modified via a highly stereospecific reduction to give homochiral α-alkoxy carboxylic acids which are useful chiral auxiliaries and intermediates.