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99592-39-9

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99592-39-9 Usage

Description

Sertaconazole nitrate is a new broad spectrum imidazole antifungal agent introduced in a topical formulation for the treatment of cutaneous infections. Its mechanism of action is the inhibition of ergosterol synthesis and interference with the permeability of fungus cell membranes. An oral formulation is currently under investigation for the treatment of bucco-pharyngeal fungal infections.

Chemical Properties

Off-White Solid

Uses

Antibacterial;ergosterol synthesis inhibitor

Brand name

Dermofix; Zalain

Check Digit Verification of cas no

The CAS Registry Mumber 99592-39-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,5,9 and 2 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 99592-39:
(7*9)+(6*9)+(5*5)+(4*9)+(3*2)+(2*3)+(1*9)=199
199 % 10 = 9
So 99592-39-9 is a valid CAS Registry Number.

99592-39-9 Well-known Company Product Price

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  • Sigma-Aldrich

  • (S0460000)  Sertaconazole nitrate  European Pharmacopoeia (EP) Reference Standard

  • 99592-39-9

  • S0460000

  • 1,880.19CNY

  • Detail
  • Sigma

  • (SML0888)  Sertaconazole nitrate  ≥98% (HPLC)

  • 99592-39-9

  • SML0888-10MG

  • 361.53CNY

  • Detail
  • Sigma

  • (SML0888)  Sertaconazole nitrate  ≥98% (HPLC)

  • 99592-39-9

  • SML0888-50MG

  • 1,481.22CNY

  • Detail

99592-39-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole,nitric acid

1.2 Other means of identification

Product number -
Other names Dermoseptic

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:99592-39-9 SDS

99592-39-9Synthetic route

3-Bromomethyl-7-chlorobenzothiophene
17512-61-7

3-Bromomethyl-7-chlorobenzothiophene

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol
24155-42-8

1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

sertaconazole nitrate
99592-39-9

sertaconazole nitrate

Conditions
ConditionsYield
Stage #1: 3-Bromomethyl-7-chlorobenzothiophene; 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol With tetrabutyl-ammonium chloride; sodium hydroxide In water; toluene at 80℃; for 4h;
Stage #2: With nitric acid
95.7%
1-[2-(7-chlorobenzo[b]thiophene-3-yl-methoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate monohydrate

1-[2-(7-chlorobenzo[b]thiophene-3-yl-methoxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole mononitrate monohydrate

sertaconazole nitrate
99592-39-9

sertaconazole nitrate

Conditions
ConditionsYield
With nitric acid In ethanol; water at 10 - 80℃; for 6 - 8h;93.9%
1-(2-chlorophenylthio)propan-2-one
17514-52-2

1-(2-chlorophenylthio)propan-2-one

sertaconazole nitrate
99592-39-9

sertaconazole nitrate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: polyphosphoric acid / 5 h / 120 - 140 °C / Large scale
2.1: benzyl chloride / tetrachloromethane / Irradiation; Heating; Large scale
2.2: 5 h / Large scale
3.1: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 4 h / 80 °C
View Scheme
2-chlorothiphenol
6320-03-2

2-chlorothiphenol

sertaconazole nitrate
99592-39-9

sertaconazole nitrate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide / water / 0.5 h / 20 °C / Large scale
1.2: 1 h / Large scale
2.1: polyphosphoric acid / 5 h / 120 - 140 °C / Large scale
3.1: benzyl chloride / tetrachloromethane / Irradiation; Heating; Large scale
3.2: 5 h / Large scale
4.1: tetrabutyl-ammonium chloride; sodium hydroxide / water; toluene / 4 h / 80 °C
View Scheme

99592-39-9Downstream Products

99592-39-9Relevant articles and documents

Preparation process of sertaconazole nitrate

-

, (2021/04/26)

The invention provides a preparation process of sertaconazole nitrate. The preparation process comprises the following steps: acylating, cyclizing, brominating, salifying and refining to obtain the finished product of sertaconazole nitrate. By adopting the preparation process of sertaconazole nitrate, the obtained finished product of sertaconazole nitrate is high in purity and high in yield. By adopting the preparation process of the sertaconazole nitrate, the raw materials are fully reacted, the generation of impurities is effectively reduced, the purity of a crude product is greatly improved, finally, the finished product of the sertaconazole nitrate obtained by adopting a refining process is high in purity and yield, and the production benefit of a sertaconazole nitrate bulk drug is effectively improved.

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