99614-70-7

Basic information

• Product Name: carbazol-4-one hydrochloride
• Synonyms: carbazol-4-one hydrochloride;1,2,3,9-tetrahydro-9-methyl-3-[(2-methylamino)methyl]-4h-carbazol-4-one;3-(DIMETHYLAMINO METHYL)-1,2,3,9-TETRAHYDRO-9-METHYL-4H-CARBAZOLE-4-ONE HCL;3-[2-(Dimethylamino)Methyl]-1,2,3,9-Tetrahydro-9-Methyl-4h-Carbazol-4-One HCl;3-[-(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one hdryochloride;3-[(dimethylamino)methyl]-1,2,;4H-carbazol-4-one hydrochloride
• CAS NO: 99614-70-7
• Molecular Formula: C12H8ClNO
• Molecular Weight: 217.65
• Product Categories: Amines
• Mol File: 99614-70-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 443.6 °C at 760 mmHg
• Flash Point: 222.1 °C
• Appearance: /
• Vapor Pressure: 6.1E-08mmHg at 25°C
• CAS DataBase Reference: carbazol-4-one hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: carbazol-4-one hydrochloride(99614-70-7)
• EPA Substance Registry System: carbazol-4-one hydrochloride(99614-70-7)

Safety Data

• Hazardous Substances Data: 99614-70-7(Hazardous Substances Data)

Usage

General Description

Carbazol-4-one hydrochloride is a chemical compound with the formula C12H9NO.HCl. It is a synthetic derivative of carbazoles, which are heterocyclic aromatic compounds. Carbazol-4-one hydrochloride has a wide range of applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of various medications. It is also used in the manufacturing of dyes and pigments, as well as in research and development as a building block for organic synthesis. The hydrochloride form of carbazol-4-one allows for improved solubility and stability, making it easier to handle and use in various chemical processes.

InChI:InChI=1/C12H7NO.ClH/c14-11-7-3-6-10-12(11)8-4-1-2-5-9(8)13-10;/h1-7H;1H

Upstream product

• 50-00-0 formaldehyd 
• 27387-31-1 9-methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one 
• 506-59-2 N,N-dimethylammonium chloride 

Relevant articles and documents

A ONE-POT PROCESS FOR THE PREPARATION OF ANTIEMETIC AGENT, 1,2,3,9-TETRAHYDRO-9-METHYL-3[(2-METHYL)-1H-IMIDAZOLE-1-YL)METHYL]-4H-CARBAZOL-4-O

A one-pot industrial process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-4H-carbazol-4-one of Formula-(I) from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one of Formula-(IV) involves reaction of Formula (IV) with HNR1R2 salt and paraformaldehyde, where R1,R2 are independently alkyl groups or together forms a cyclic alkyl group, in a solvent system of acetic acid and hydrocarbon solvent to form a crude mixture of intermediate compounds of Formula (III) and (VIII), which is converted to ondansetron (Formula (I)) without isolation by reaction with 2-methyimidazole in a suitable solvent system in the same pot.