99724-19-3

Basic information

• Product Name: 3-N-Boc-aminopyrrolidine
• Synonyms: 3-(BOC-AMINO)PYRROLIDINE;3-N-BOC-AMINO PYRROLIDINE;3-PYRROLIDINYL-CARBAMIC ACID TERT-BUTYL ESTER;3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE;BOC-(+/-)-3-AMINOPYRROLIDINE;BOC-(+/-)-(3)APYROLIDI;TERT-BUTYL PYRROLIDIN-3-YLCARBAMATE;PYRROLIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER
• CAS NO: 99724-19-3
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• Product Categories: pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;3-Aminopyrrolidines;3-Aminopyrrolidines (Racemic);Amines;Pyrrolidines
• Mol File: 99724-19-3.mol
• Article Data: 10

Chemical Properties

• Melting Point: 67 °C
• Boiling Point: 286.4 °C at 760 mmHg
• Flash Point: 127 °C
• Appearance: /
• Density: 1.04 g/cm³
• Vapor Pressure: 0.00264mmHg at 25°C
• Storage Temp.: 2-8°C
• Solubility: Soluble in Methanol(almost transparency).
• PKA: 12.37±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 3-N-Boc-aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-N-Boc-aminopyrrolidine(99724-19-3)
• EPA Substance Registry System: 3-N-Boc-aminopyrrolidine(99724-19-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 99724-19-3(Hazardous Substances Data)

Usage

Description

3-N-Boc-aminopyrrolidine, also known as (+/-)-3-(Boc-amino)pyrrolidine, is a homochiral starting material used in the synthesis of various chiral compounds. It is a versatile building block in organic chemistry, particularly in the development of pharmaceuticals and bioactive molecules.

Uses

Used in Pharmaceutical Synthesis:
3-N-Boc-aminopyrrolidine is used as a key intermediate in the synthesis of chiral compounds for pharmaceutical applications. Its unique structure and reactivity make it a valuable component in the creation of new drugs and therapeutic agents.
Used in Peptide Synthesis:
3-N-Boc-aminopyrrolidine is used as a reactant in the synthesis of peptides, specifically in the development of peptide-based drugs and therapeutic agents. Its ability to form stable peptide bonds contributes to the overall stability and effectiveness of the final peptide product.
Used in G-Protein Coupled Receptors Test:
3-N-Boc-aminopyrrolidine is used as a reactant in the peptide activated G-protein coupled receptors test. This test is crucial in evaluating the interaction between peptides and G-protein coupled receptors, which play a significant role in cellular signaling and various physiological processes.

InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-7-4-5-10-6-7/h7,10H,4-6H2,1-3H3,(H,11,12)/p+1/t7-/m0/s1

Upstream product

• 99735-30-5 N-benzyl-3-(R)-((1,1-dimethylethoxycarbonyl)amino)pyrrolidine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79286-79-6 (3S)-3-aminopyrrolidine 

Downstream Products

• 112811-60-6 1-Cyclopropyl-6-fluoro-8-methoxy-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid 
• 146981-09-1 5-amino-7-(3-amino-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid 
• 182868-77-5 1-cyclopropyl-6-fluoro-8-ethoxy-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
• 635309-36-3 ethyl 7-(3-((tert-butoxycarbonyl)amino)pyrrolidin-1-yl)-1-(2,4-dimethoxybenzyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate 
• 815618-84-9 4-bromo-3-[3-(tert-butoxycarbonylamino)pyrrolidin-1-yl]-1-chloro-6-(2,4-dimethoxybenzyl)-9-oxo-6,9-dihydro-5H-pyrido[4,3-c]azepine-8-carboxylic acid ethyl ester 
• 850418-40-5 (3-tert-butoxycarbonylamino-pyrrolidin-1-yl)-phenyl-acetic acid methyl ester 
• 816424-94-9 rac-tert-butyl [1-({3-[(2,4-difluorophenyl)amino]-6-oxo-7-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl}carbonyl)pyrrolidin-3-yl]carbamate 
• 185057-49-2 (S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinecarboxylic acid,phenylmethyl ester 
• 888972-36-9 [1-(phenylsulfonyl)-3-pyrrolidinyl]-carbamic acid, 1,1-dimethylethyl ester 
• 391903-23-4 N-[1-(3-Amino-4-nitrophenyl)pyrrolidin-3-yl] (tert-butoxy)carboxamide 
• 457097-99-3 (3S)-3-(tert-butoxycarbonylamino)-1-(4-fluoro-benzyl)-pyrrolidine 
• 350854-24-9 1-[(4-Cyano-5-methyl-4-phenyl)hexyl]-3-tert-butoxycarbonylaminopyrrolidine 

Relevant articles and documents

NAPHTHALENYLOXYPROPENYL DERIVATIVES HAVING INHIBITORY ACTIVITY AGAINST HISTONE DEACETYLASE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention discloses novel naphthalenyloxypropenyl derivatives useful for inhibiting the enzyme activity of histone deacetylase, leading effective suppression of cancer cell proliferation

PROCESS FOR PRODUCING 1-ALKOXYCARBONYL NITROGENOUS SATURATED HETEROCYCLIC DERIVATIVE

A method for producing N-protected heterocyclic compounds such as 1-alkoxycarbonyl-3-aminopyrrolidines through position-selective reaction at the nitrogen atom that constitutes the hetero ring of a nitrogen-containing saturated heterocyclic compound having two nitrogen atoms such as 3-aminopyrrolidine. A dialkyl dicarbonate (ROCO-O-COOR) is reacted with a nitrogen-containing saturated heterocyclic compounds having two nitrogen atoms, at pH of from 9 to 14 to obtain a high-purity 1-alkoxycarbonyl nitrogen-containing saturated heterocyclic compound.

Naphthyridine antibacterial agents

Novel naphthyridine-carboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections.