99790-15-5Relevant articles and documents
N-carbamate protected amino acid derived guanidine organocatalysts
Al-Taie, Zahraa S.,Anderson, Joseph M.,Bischoff, Laura,Christensen, Jeppe,Coles, Simon J.,Froom, Richard,Gibbard, Mari E.,Jones, Leigh F.,de Kleijne, Frank F.J.,Murphy, Patrick J.,Thompson, Emma C.
, (2021)
We report the preparation of a range of N-protected amino acid derived guanidine organocatalysts and their application to the Michael addition of 2-hydroxy-1,4-napthoquinone to β-nitrostyrene, achieving a maximum ee of 26%. Whilst these catalysts gave poo
A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H
Ivkovic, Jakov,Lembacher-Fadum, Christian,Breinbauer, Rolf
supporting information, p. 10456 - 10460 (2015/11/10)
N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.
Total synthesis of halipeptins A and D and analogues
Nicolaou,Kim, David W.,Schlawe, Daniel,Lizos, Dimitrios E.,De Noronha, Rita G.,Longbottom, Deborah A.
, p. 4925 - 4929 (2007/10/03)
(Chemical Equation Presented) Deceptive rings: Halipeptins A (1 a) and D (1 b) and analogues thereof were synthesized from fragments 2 and 3 a, b, respectively. Key steps included peptide-bond formation, DAST-induced thiazoline construction, and macrolact