99802-88-7

Basic information

• Product Name: Pyrrolidine, 1-(4-hydroxy-1-oxo-4-phenylbutyl)-
• CAS NO: 99802-88-7
• Molecular Formula: C14H19NO2
• Molecular Weight: 233.31
• Mol File: 99802-88-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-(4-hydroxy-1-oxo-4-phenylbutyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(4-hydroxy-1-oxo-4-phenylbutyl)-(99802-88-7)
• EPA Substance Registry System: Pyrrolidine, 1-(4-hydroxy-1-oxo-4-phenylbutyl)-(99802-88-7)

Safety Data

• Hazardous Substances Data: 99802-88-7(Hazardous Substances Data)

Upstream product

• 2051-95-8 succinylbenzene 
• 53917-82-1 β-benzoylpropionyl chloride 
• 123-75-1 pyrrolidine 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 51459-75-7 1-phenyl-4-(pyrrolidine-1-yl) butane-1,4-dione 

Downstream Products

• 100420-10-8 4-phenyl-1-(pyrrolidin-1-yl)butan-1-one 
• 1453171-96-4 4-(tert-butyldimethylsilyloxy)-4-phenyl-1-(pyrrolidin-1-yl)butan-1-one 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 51459-75-7 1-phenyl-4-(pyrrolidine-1-yl) butane-1,4-dione 
• 99802-92-3 2-(4-hydroxy-4-phenylbutanoyl)-1-methyl-1H-imidazole 

Relevant articles and documents

Visible light photoredox-catalyzed deoxygenation of alcohols

Carbon-oxygen single bonds are ubiquitous in natural products whereas efficient methods for their reductive defunctionalization are rare. In this work an environmentally benign protocol for the activation of carbon-oxygen single bonds of alcohols towards a reductive bond cleavage under visible light photocatalysis was developed. Alcohols were activated as 3,5-bis(trifluoromethyl)-substituted benzoates and irradiation with blue light in the presence of [Ir(ppy)2( dtb-bpy)](PF6 ) as visible light photocatalyst and Hünig's base as sacrificial electron donor in an acetonitrile/water mixture generally gave good to excellent yields of the desired defunctionalized compounds. Functional group tolerance is high but the protocol developed is limited to benzylic, α-carbonyl, and α-cyanoalcohols; with other alcohols a slow partial C-F bond reduction in the 3,5-bis(trifluoromethyl)benzoate moiety occurs.

Direct room-temperature lactonisation of alcohols and ethers onto amides: An "amide strategy" for synthesis

Last-minute deal: A direct lactonisation of ethers and alcohols onto amides that proceeds at room temperature under mild conditions is reported (see scheme). This allows the effective saving of up to two unproductive, sequential deprotection operations in synthetic sequences. Mechanistic studies are described, and a new "amide strategy" that exploits the dual robustness/late-stage selective activation properties of this functional group is outlined. Copyright

Synthesis and Application of Imidazole Derivatives. Synthesis and Acyl Activation of 2-Acyl-1-methyl-1H-imidazoles

2-Acyl-1-methyl-1H-imidazoles (3) were prepared in good yields by treating 1-acylpyrrolidines (5) with 2-lithio-1-methyl-1H-imidazole (2) at -78 deg C.The acyl group of 3 was very stable under various severe conditions, but 2-benzoylimidazole (3a) was gradually hydrolyzed by heating with 1.3 N NaOH to produce benzoic acid and 1-methyl-1H-imidazole.Acyl activation of 3 was performed by direct quaternization of 3 with iodomethane or dimethyl sulfate or more successfully by quaternization of the corresponding O-trimethylsilylated gem-cyanohydrin (11) with dimethyl sulfate.Keywords- acylimidazole; 2-acylimidazole; imidazolium salt; acyl group activation; acylation; C-C bond fission; protecting group; latent functionality