99838-68-3Relevant articles and documents
An Enantioselective Synthesis of (5 S,6 R,11 S,14 R)-Acremodiol
Dey, Papiya,Chatterjee, Sucheta,Gamre, Sunita S.,Chattopadhyay, Subrata,Sharma, Anubha
, p. 5231 - 5237 (2017/11/28)
An expeditious synthesis of the (5 S,6 R,11 S,14 R)-isomer of acremodiol was developed via a convergent route. One of the required building blocks was synthesized earlier via two sequential lipase-catalyzed secondary carbinol acetylations. The other unit
Selective synthetic method of natural products Xylapyrroside A
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Paragraph 0034; 0035, (2017/05/16)
The invention belongs to the field of chemical synthesis, and relates to a selective synthetic method of natural products Xylapyrroside A. According to the invention, (R)-(+)-2,2-dimethyl-1,3-dioxolane-4-formaldehyde is taken as an initial raw material, a Grignard reaction, hydroxy benzyl protection, acetonide protection removal, hydroxy selective tert-butyl dimethyl silicon and benzyl protection, terminal double bond epoxidation and iodo ring opening and oxidation are carried out to obtain (4S,5R)-4,5-di-benzyloxy-6-tert-butyldimethylsilyloxy-1-n-amyl iodide-2-ketone, the product is subjected to condensation with another intermediate 5-(((tetrahydro-2H-pyrans-2-group)oxygen)methyl)-1H-pyrroles-2-formaldehyde under alkaline condition, and then the product is subjected to deprotection and cyclization, and finally the target product is synthesized. The method has the advantages of simple operation and high yield, and a reagent has the advantages of low cost and easy acquisition of the raw materials.
The protecting-group directed diastereoselective Nozaki-Hiyama-Kishi (NHK) reaction: Total synthesis and biological evaluation of zeaenol, 7-epi-zeaenol and its analogues
Mohapatra, Debendra K.,Reddy, D. Sai,Mallampudi, N. Arjunreddy,Gaddam, Janardhan,Polepalli, Sowjanya,Jain, Nishant,Yadav
, p. 9683 - 9695 (2015/02/19)
The stereoselective total synthesis of zeaenol and 7-epi-zeaenol is achieved in a convergent manner using Julia-Kocienski olefination, protecting group-directed intermolecular diastereoselective Nozaki-Hiyama-Kishi (NHK) reaction, De Brabander's lactoniza