99846-93-2 Usage
General Description
2',5'-DICHLOROPROPIOPHENONE is a chemical compound with the molecular formula C9H7Cl2O. It is a white crystalline solid that is soluble in organic solvents but insoluble in water. 2',5'-DICHLOROPROPIOPHENONE is often used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has also been researched for its potential use as a chemical intermediate in the production of dyes and pigments. Additionally, 2',5'-DICHLOROPROPIOPHENONE is known to have some antimicrobial properties, making it useful in certain industrial and medical applications. However, it is important to handle this compound with caution, as it may pose health and environmental risks due to its toxic and potentially hazardous nature.
Check Digit Verification of cas no
The CAS Registry Mumber 99846-93-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,9,8,4 and 6 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 99846-93:
(7*9)+(6*9)+(5*8)+(4*4)+(3*6)+(2*9)+(1*3)=212
212 % 10 = 2
So 99846-93-2 is a valid CAS Registry Number.
99846-93-2Relevant articles and documents
Discovery of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as potent RORγt inverse agonists
Wang, Yonghui,Yang, Ting,Liu, Qian,Ma, Yingli,Yang, Liuqing,Zhou, Ling,Xiang, Zhijun,Cheng, Ziqiang,Lu, Sijie,Orband-Miller, Lisa A.,Zhang, Wei,Wu, Qianqian,Zhang, Kathleen,Li, Yi,Xiang, Jia-Ning,Elliott, John D.,Leung, Stewart,Ren, Feng,Lin, Xichen
, p. 5293 - 5302 (2015/11/10)
A novel series of N-(4-aryl-5-aryloxy-thiazol-2-yl)-amides as RORγt inverse agonists was discovered. Binding mode analysis of a RORγt partial agonist (2c) revealed by co-crystal structure in RORγt LBD suggests that the inverse agonists do not directly interfere with the interaction between H12 and the RORγt LBD. Detailed SAR exploration led to identification of potent RORγt inverse agonists such as 3m with a pIC50 of 8.0. Selected compounds in the series showed reasonable activity in Th17 cell differentiation assay as well as low intrinsic clearance in mouse liver microsomes.
