99848-43-8

Basic information

• Product Name: 2-Bromo-5-methoxybenzamide, 98
• Synonyms: 2-Bromo-5-methoxybenzamide, 98
• CAS NO: 99848-43-8
• Molecular Formula: C₈H₈BrNO₂
• Molecular Weight: 230.06
• Mol File: 99848-43-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 159-161℃
• Appearance: /
• CAS DataBase Reference: 2-Bromo-5-methoxybenzamide, 98(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-methoxybenzamide, 98(99848-43-8)
• EPA Substance Registry System: 2-Bromo-5-methoxybenzamide, 98(99848-43-8)

Safety Data

• Hazardous Substances Data: 99848-43-8(Hazardous Substances Data)

Usage

Description

2-Bromo-5-methoxybenzamide, 98 is a chemical compound that is a derivative of benzamide, featuring a bromine atom and a methoxy group on the benzene ring. Known for its high purity level of 98%, it is utilized in various chemical and pharmaceutical applications, making it a valuable reagent in organic synthesis and medicinal chemistry research. Its molecular structure and properties render it suitable for a wide range of chemical reactions and as a building block in the development of new pharmaceuticals and specialty chemicals.

Uses

Used in Chemical Synthesis:
2-Bromo-5-methoxybenzamide, 98 is used as a reagent in chemical synthesis for its ability to participate in diverse chemical reactions, contributing to the creation of new compounds and materials.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Bromo-5-methoxybenzamide, 98 is used as a building block in the development of new pharmaceuticals. Its unique molecular structure allows it to be a key component in the design and synthesis of potential drug candidates.
Used in Medicinal Chemistry:
2-Bromo-5-methoxybenzamide, 98 is utilized in medicinal chemistry research to explore its potential interactions with biological targets, which can lead to the discovery of new therapeutic agents and treatments.
Used in Specialty Chemicals Development:
2-Bromo-5-methoxybenzamide, 98 is also used in the development of specialty chemicals, where its specific properties can be leveraged to create high-value products for various industries.

Upstream product

• 5813-86-5 m-methoxybenzamide 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 
• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 

Downstream Products

• 887581-09-1 (2-bromo-5-methoxyphenyl)methanamine 
• 63874-34-0 2-ethoxy-5-methoxybenzamide 
• 1151-70-8 6-methoxy-2-phenyl-quinazolinone-4(3H)-one 
• 1157-63-7 6-methoxy-2-(4-methoxyphenyl)-quinazolin-4(3H)-one 
• 1269219-58-0 6-methoxy-2-(4-methylphenyl)-quinazolin-4(3H)-one 
• 1425605-60-2 5-methoxy-2-(pentadec-1-yn-1-yl)benzamide 
• 1425605-92-0 7-methoxy-3-phenylisoquinolin-1-amine 
• 1338797-89-9 5-methoxy-2-(phenylethynyl)benzamide 
• 1207252-48-9 2-(hex-1-ynyl)-5-methoxybenzamide 
• 1255775-74-6 2-(5-hydroxypent-1-ynyl)-5-methoxybenzamide 
• 16027-16-0 7-methoxy-2H-isoquinolin-1-one 
• 131002-08-9 2-ethenyl-5-methoxybenzamide 
• 62265-91-2 7-methoxy-3-phenylisoquinolin-1(2H)-one 
• 138642-47-4 2-bromo-5-methoxybenzonitrile 

Relevant articles and documents

Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold

The COVID-19 pandemic has drastically impacted global economies and public health. Although vaccine development has been successful, it was not sufficient against more infectious mutant strains including the Delta variant indicating a need for alternative treatment strategies such as small molecular compound development. In this work, a series of SARS-CoV-2 main protease (Mpro) inhibitors were designed and tested based on the active compound from high-throughput diverse compound library screens. The most efficacious compound (16b-3) displayed potent SARS-CoV-2 Mpro inhibition with an IC50 value of 116 nM and selectivity against SARS-CoV-2 Mpro when compared to PLpro and RdRp. This new class of compounds could be used as potential leads for further optimization in anti COVID-19 drug discovery.

Method for synthesizing chlorantraniliprole derivative intermediate

The invention provides a method for synthesizing a chlorantraniliprole derivative intermediate, belonging to the field of agricultural pesticides. The method comprises the following steps: subjectingthe intermediate 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid to chlorination so as to prepare 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-formyl chloride; subjecting the raw material 2-bromobenzoic acid to acylating chlorination and ammoniation so as to prepare substituted 2-bromo-benzamide; and subjecting 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-formyl chloride and substituted 2-bromo-benzamide to cyclization so as to obtain the chlorantraniliprole derivative intermediate. The method of the invention is simple and common; reagents used in the process of synthesis are low in toxicity, used solvents are recyclable, and few by-products are produced, so the method has little corrosion to equipment and low pollution to environment; since raw materials are cheap, production cost is reduced and good economical efficiency is obtained; therefore, the method has good application prospects.

Certain pyrazoline derivatives with kinase inhibitory activity

The present invention provides certain pyrazoline compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions and methods of using the compositions in the treatment of various diseases.