99981-59-6

Basic information

• Product Name: 3-[{(4-methylphenyl)methyl}amino]propanamide
• Synonyms: 3-[{(4-methylphenyl)methyl}amino]propanamide
• CAS NO: 99981-59-6
• Molecular Weight: 192.261
• Mol File: 99981-59-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[{(4-methylphenyl)methyl}amino]propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[{(4-methylphenyl)methyl}amino]propanamide(99981-59-6)
• EPA Substance Registry System: 3-[{(4-methylphenyl)methyl}amino]propanamide(99981-59-6)

Safety Data

• Hazardous Substances Data: 99981-59-6(Hazardous Substances Data)

Upstream product

• 79-06-1 2-propenamide 
• 104-84-7 para-methylbenzylamine 

Downstream Products

• 100614-64-0 N-dichloroacetyl-N-(4-methyl-benzyl)-β-alanine amide 

Relevant articles and documents

Synthesis and biological evaluation of 4-hydroxy-5-oxo-2,5-dihydro-1: H -pyrrole-3-carboxamides and their zinc(II) complexes as candidate antidiabetic agents

The newly designed 1-(arylmethyl)-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxamides (1a-e) were synthesized by using N-tritylated acrylamide as a starting material, and their zinc(ii) complexes (10a-e) were readily prepared by simply mixing 1a-e and ZnSO4 in the presence of LiOH. The aldose reductase (AR) inhibitory activity of 1a-e was evaluated to reveal important structural features for 2,5-dihydro-5-oxo-1H-pyrrole derivatives to exhibit high AR inhibitory activity. The in vitro insulin-mimetic activity of these complexes was evaluated from 50% inhibitory concentrations (IC50) on free fatty acid (FFA) release from isolated rat adipocytes treated with epinephrine. Four out of the five newly synthesized complexes exhibited higher in vitro insulin-mimetic activities than ZnSO4, a positive control. This study proved that the newly synthesized N2O2-coordination-type zinc(ii) complexes based on pyrrole-3-carboxamide derivatives (1a-d) are potential hypoglycemic agents.