1 - Product and Company Information

Product Name ISOBUTYRIC ACI Product Number I1754
2 - Composition/Information on Ingredients

Product Name CAS # EC no Annex I
Index Number
ISO-BUTYRIC ACID 79-31-2 201-195-7 607-063-00-9

Formula C4H8O2
Molecular Weight 88.11 AMU
Synonyms Acetic acid, dimethyl- * Dimethylacetic acid *
Isopropylformic acid * Kyselina isomaselna
(Czech) * alpha-Methylpropionic acid *
2-Methylpropanoic acid * 2-Methylpropionic acid
* Propionic acid, 2-methyl-

3 - Hazards Identification

SPECIAL INDICATION OF HAZARDS TO HUMANS AND THE ENVIRONMENT
Harmful in contact with skin and if swallowed.


4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.

AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.

AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.

AFTER INGESTION
 If swallowed, wash out mouth with water provided person is
conscious. Call a physician. Do not induce vomiting.

5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Carbon dioxide, dry chemical powder, or appropriate
foam.

SPECIAL RISKS
Specific Hazard(s): Combustible liquid. Emits toxic fumes under
fire conditions.

SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures

PERSONAL PRECAUTION PROCEDURES TO BE FOLLOWED IN CASE OF LEAK OR SPILL
Evacuate area.

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear self-contained breathing apparatus, rubber boots, and heavy
rubber gloves.

METHODS FOR CLEANING UP
Cover with dry lime or soda ash, pick up, keep in a closed
container, and hold for waste disposal. Ventilate area and wash
spill site after material pickup is complete.

7 - Handling and Storage

HANDLING
Directions for Safe Handling: Do not breathe vapor. Do not get
in eyes, on skin, on clothing. Avoid prolonged or repeated
exposure.

STORAGE
Conditions of Storage: Keep tightly closed. Keep away from heat
and open flame. Store in a cool dry place.

SPECIAL REQUIREMENTS: Stench.

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Use only in a chemical fume hood.

GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse. Discard contaminated
shoes. Wash thoroughly after handling.

PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Government approved respirator.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.
Special Protective Measures: Faceshield (8-inch minimum).

9 - Physical and Chemical Properties

Appearance Physical State: Clear liquid


SIGMA - I1754 www.-aldrich.com  Color: Colorless

Property Value At Temperature or Pressure

pH 2.5 20 ??C Concentration: 100
g/l
BP/BP Range 154 - 155 ??C
MP/MP Range -47 ??C
Flash Point 55 ??C Method: closed cup
Flammability N/A
Autoignition Temp 440 ??C
Oxidizing Properties N/A
Explosive Properties N/A
Explosion Limits Lower: 2 %
Upper: 10 %
Vapor Pressure 1.5 mmHg 20 ??C
SG/Density 0.949 g/cm3
Partition Coefficient Log Kow: 0.88
Viscosity 1.13 Pas 30 ??C
Vapor Density 3.04 g/l
Saturated Vapor Conc. N/A
Evaporation Rate N/A
Bulk Density N/A
Decomposition Temp. N/A
Solvent Content N/A
Water Content < 0.2 %
Surface Tension 25.2 mN/m 25 ??C
Conductivity N/A
Miscellaneous Data N/A
Solubility Solubility in Water:Soluble.
Other Solvents: MISCIBLE IN ALCOHOL, ETHE CHLOROFORM

10 - Stability and Reactivity

STABILITY
Stable: Stable.
Materials to Avoid: Strong oxidizing agents.

HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide.

HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

11 - Toxicological Information

RTECS NUMBER: NQ4375000

ACUTE TOXICITY

LD50
Oral
Rat
280 UL/KG

LD50
Skin
Rabbit
500 UL/KG

IRRITATION DATA


SIGMA - I1754 www.-aldrich.com  Skin
Rabbit
0.139 mg
24H
Remarks: Open irritation test

SIGNS AND SYMPTOMS OF EXPOSURE
Material is extremely destructive to tissue of the mucous
membranes and upper respiratory tract, eyes, and skin.
Inhalation may result in spasm, inflammation and edema of the
larynxand bronchi, chemical pneumonitis, and pulmonary edema.
Symptoms of exposure may include burning sensation, coughing,
wheezing, laryngitis, shortness of breath, headache, nausea, and
vomiting.

ROUTE OF EXPOSURE
Skin Contact: Causes burns.
Skin Absorption: Harmful if absorbed through skin. Readily
absorbed through skin.
Eye Contact: Causes burns.
Inhalation: May be harmful if inhaled. Material is extremely
destructive to the tissue of the mucous membranes and upper
respiratory tract.
Ingestion: Harmful if swallowed.

12 - Ecological Information

ECOTOXICOLOGICAL EFFECTS

Test Type: EC50 Algae
Species: Scenedesmus subspicatus
Time: 72 h
Value: 45 mg/l

Test Type: EC50 Daphnia
Species: Daphnia magna
Time: 24 h
Value: 1,000 mg/l

Test Type: LC50 Fish
Species: Leuciscus idus
Time: 48 h
Value: 193 mg/l

Test Type: LC50 Fish
Species: Onchorhynchus mykiss (Rainbow trout)
Time: 96 h
Value: 286 mg/l

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Contact a licensed professional waste disposal service to dispose
of this material. Dissolve or mix the material with a combustible
solvent and burn in a chemical incinerator equipped with an
afterburner and scrubber. Observe all federal, state, and local
environmental regulations.

14 - Transport Information

RID/AD

SIGMA - I1754 www.-aldrich.com  UN#: 2529
Class: 3
PG: III
Proper Shipping Name: Isobutyric acid

IMDG
UN#: 2529
Class: 3
PG: III
Subrisk: 8
Proper Shipping Name: Isobutyric acid
Marine Pollutant: No
Severe Marine Pollutant: No

IATA
UN#: 2529
Class: 3
PG: III
Subrisk: 8
Proper Shipping Name: Isobutyric acid
Inhalation Packing Group I: No

15 - Regulatory Information

CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
ANNEX I INDEX NUMBER: 607-063-00-9
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 21/22
Harmful in contact with skin and if swallowed.

COUNTRY SPECIFIC INFORMATION

Germany
WGK: 1

SWITZERLAN SWISS POISON CLASS: 3

16 - Other Information

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Sigma-Aldrich Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2005 Sigma-Aldrich Co. License granted to make unlimited
paper copies for internal use only.

DISCLAIME For R&D use only. Not for drug, household or other uses.




SIGMA - I1754 www.-aldrich.com 

Isobutyric acid