1-Naphthalenamine,
4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-,
hydrochloride, (1S-cis)-

CAS  

 79559-97-0

SYNONYMS  

 * Sertraline hydrochloride

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QJ0352070
CHEMICAL NAME           : 1-Naphthalenamine,
                          4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-,
                          hydrochloride, (1S-cis)-
CAS REGISTRY NUMBER     : 79559-97-0
LAST UPDATED            : 199606
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H17-Cl2-N.Cl-H
MOLECULAR WEIGHT        : 342.71
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Sertraline hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 7 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - headache
   Musculoskeletal - changes in teeth and supporting structures
   Skin and Appendages - sweating
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 54,432,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 7 mg/kg/7D-I
TOXIC EFFECTS :
   Behavioral - excitement
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 54,321,1993
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 56 mg/kg
SEX/DURATION            : female 5 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - breasts, lactation (prior to or during
   pregnancy)
REFERENCE :
   AJPSAO American Journal of Psychiatry.  (American Psychiatric Assoc.,
   Circulation Dept., 1400 K St., NW, Washington, DC 20005)  V.78-    1921-
   Volume(issue)/page/year: 150,1269,1993
 
                            *** END OF RECORD ***