Material Safety Data Sheet
2-(4-Chlorosulfonylphenyl)ethyltrimethoxysilane 50% solution in dichloromethane

Section 1 - Chemical Product and Company Identification
MSDS Name: 2-(4-Chlorosulfonylphenyl)ethyltrimethoxysilane 50% solution in dichloromethane
Catalog Numbers: 33747-0000, 33747-0050
Synonyms:
Acros Organics BVBA
Company Identification: Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium
Acros Organics
Company Identification: (USA) One Reagent Lane
Fair Lawn, NJ 07410
For information in the US, call: 800-ACROS-01
For information in Europe, call: +32 14 57 52 11
Emergency Number, Europe: +32 14 57 52 99
Emergency Number US: 201-796-7100
CHEMTREC Phone Number, US: 800-424-9300
CHEMTREC Phone Number, Europe: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# Chemical Name: % EINECS# Hazard Symbols: Risk Phrases:
75-09-2 Dichloromethane 200-838-9 XN 40
79793-00-3 2-(4-Chlorosulfonylphenyl)ethyltrimethoxysilane 50% 279-267-2
Text for R-phrases: see Section 16
Hazard Symbols: C




Risk Phrases: 34 40
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Causes burns. Limited evidence of a carcinogenic effect.Moisture sensitive.
Potential Health Effects
Eye: Causes eye burns.
Skin: Causes skin burns. May be harmful if absorbed through the skin.
Ingestion: Causes gastrointestinal tract burns. May be harmful if swallowed.
Inhalation: Causes chemical burns to the respiratory tract. May be harmful if inhaled.
Chronic:
Section 4 - First Aid Measures
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical
Eyes:
aid immediately.
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated
Skin:
clothing and shoes.
 Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or
Ingestion:
water.
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If not breathing, give artificial
Inhalation:
respiration. If breathing is difficult, give oxygen.
Notes to
Physician:
Section 5 - Fire Fighting Measures
General As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and
Information: full protective gear.
Extinguishing
Use water spray, dry chemical, carbon dioxide, or chemical foam.
Media:
Section 6 - Accidental Release Measures
General
Use proper personal protective equipment as indicated in Section 8.
Information:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Spill may be carefully
Spills/Leaks:
neutralized with lime (calcium oxide, CaO).
Section 7 - Handling and Storage
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood.
Store in a cool, dry place. Store in a tightly closed container. Corrosives area. Store protected from moisture. Keep away from acidic,
Storage:
alkaline, combustible and oxidizing materials.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to
keep airborne concentrations low.
Exposure Limits
CAS# 75-09-2:
United Kingdom, WEL - TWA: 100 ppm TWA; 350 mg/m3 TWA United Kingdom, WEL - STEL: 300 ppm STEL;
1060 mg/m3 STEL
United States OSHA: ; 25 ppm TWA (8 hr); 125 ppm STEL (15 min); 12.5 ppm Action Level (See 29 CF 1910 .1052)
Belgium - TWA: 50 ppm VLE; 177 mg/m3 VLE
France - VME: 50 ppm VME; 180 mg/m3 VME France - VLE: 100 ppm VLE; 350 mg/m3 VLE
Germany: 100 ppm TWA; 350 mg/m3 TWA
Japan: 50 ppm OEL; 170 mg/m3 OEL Japan: 100 ppm Ceiling; 340 mg/m3 Ceiling
Malaysia: 50 ppm TWA
Netherlands: 500 ppm STEL; 1750 mg/m3 STEL Netherlands: 100 ppm MAC; 350 mg/m3 MAC
Russia: 50 mg/m3 TWA (vapour)
Spain: 50 ppm VLA-ED; 177 mg/m3 VLA-E CAS# 79793-00-3:


Personal Protective Equipment
Eyes: Wear chemical splash goggles.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or
Respirators:
European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Section 9 - Physical and Chemical Properties
Physical State: Clear liquid
Color: yellow
Odor: Not available
pH: Not available
Vapor Pressure: 349 mm Hg @ 20 deg C
 Viscosity: Not available
Boiling Point: > 40 deg C (> 104.00??F)
Freezing/Melting Point: Not available
Autoignition Temperature: Not available
Flash Point: Not available
Explosion Limits: Lower: 14 vol %
Explosion Limits: Upper: 22 vol %
Decomposition Temperature: Not available
Solubility in water: Reacts
Specific Gravity/Density:
Molecular Formula: C11H17ClO5SSi
Molecular Weight: 324.85
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials, contact with water.
Incompatibilities with Other Materials Water, oxidizing agents, acids, bases, alcohols.
Hazardous Decomposition Products Hydrogen chloride, carbon monoxide, oxides of sulfur, carbon dioxide.
Hazardous Polymerization Will not occur.
Section 11 - Toxicological Information
CAS# 75-09-2: PA8050000
RTECS#:
CAS# 79793-00-3: None listed
RTECS:
CAS# 75-09-2: Draize test, rabbit, eye: 162 mg Moderate;
Draize test, rabbit, eye: 10 mg Mild;
Draize test, rabbit, eye: 500 mg/24H Mild;
Draize test, rabbit, skin: 810 mg/24H Severe;
Draize test, rabbit, skin: 100 mg/24H Moderate;
Inhalation, mouse: LC50 = 14400 ppm/7H;
Inhalation, mouse: LC50 = 49100 mg/m3/6H;
Inhalation, mouse: LC50 = 54000 mg/m3/2H;
Inhalation, mouse: LC50 = 56220 mg/m3/7H;
LD50/LC50:
Inhalation, rat: LC50 = 52 gm/m3;
Inhalation, rat: LC50 = 76000 mg/m3/4H;
Inhalation, rat: LC50 = 52000 mg/m3/6H;
Oral, mouse: LD50 = 873 mg/kg;
Oral, rabbit: LD50 = 2000 mg/kg;
Oral, rat: LD50 = 1600 mg/kg;
Oral, rat: LD50 = 985 mg/kg;
.
RTECS:
CAS# 79793-00-3:.
Dichloromethane - ACGIH: A3 - Confirmed animal carcinogen with unknown relevance to humans California: carcinogen, initial
Carcinogenicity: date 4/1/88 NTP: Suspect carcinogen IARC: Group 2B carcinogen
2-(4-Chlorosulfonylphenyl)ethyltrimethoxysilane - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: See actual entry in RTECS for complete information. The toxicological properties have not been fully investigated.
Section 12 - Ecological Information
Not available
Section 13 - Disposal Considerations
Dispose of in a manner consistent with federal, state, and local regulations.
Section 14 - Transport Information
IATA IMO RID/AD Shipping Name: CORROSIVE LIQUID, N.O.S.* CORROSIVE LIQUID, N.O.S. CORROSIVE LIQUID, N.O.S.
Hazard Class: 8 8 8
UN Number: 1760 1760 1760
Packing Group: II II II
USA RQ: CAS# 75-09-2: 1000 lb final RQ; 454 kg final RQ
Section 15 - Regulatory Information
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 34 Causes burns.
R 40 Limited evidence of a carcinogenic effect.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
WGK (Water Danger/Protection)
CAS# 75-09-2: 2
CAS# 79793-00-3: Not available
Canada
CAS# 75-09-2 is listed on Canada's DSL List
CAS# 79793-00-3 is listed on Canada's NDSL List
US Federal
TSCA
CAS# 75-09-2 is listed on the TSCA Inventory.
CAS# 79793-00-3 is listed on the TSCA Inventory.
Section 16 - Other Information
Text for R-phrases from Section 2
R 40 Limited evidence of a carcinogenic effect.
MSDS Creation Date: 11/05/1999
Revision #0 Date Original.


The information above is believed to be accurate and represents the best information currently available to us. However,
we make no warranty of merchantibility or any other warranty, express or implied, with respect to such information, and
we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the
information for their particular purposes. In no event shall the company be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect, incidental, consequential, or exemplary damages howsoever arising,
even if the company has been advised of the possibility of such damages.


2-(4-Chlorosulphonylphenyl)ethyl trichlorosilanein methylene chloride