o-Toluidine, 5-chloro-

CAS  

 95-79-4

SYNONYMS  

 * Acco Fast Red KB Base
* 1-Amino-3-chloro-6-methylbenzene
* 2-Amino-4-chlorotoluene
* Ansibase Red KB
* Azoene Fast Red KB Base
* Azoic Diazo Component 32
* Benzenamine, 5-chloro-2-methyl-
* 4-Chloro-2-aminotoluene
* 3-Chloro-6-methylaniline
* 5-Chloro-2-methylaniline
* 5-Chloro-o-toluidine
* Fast Red KB amine
* Fast Red KB base
* Fast Red KB Salt
* Fast Red KB Salt Supra
* Fast Red KBS Salt
* Genazo Red KB Soln
* Hiltonil Fast Red KB Base
* Lake Red BK Base
* Metrogen Red Former KB Soln
* Naphthosol Fast Red KB Base
* NCI-C02051
* Pharmazoid Red KB
* Red KB Base
* Spectrolene Red KB
* Stable Red KB Base

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XU5075000
CHEMICAL NAME           : o-Toluidine, 5-chloro-
CAS REGISTRY NUMBER     : 95-79-4
BEILSTEIN REFERENCE NO. : 0878504
REFERENCE               : 4-12-00-01794 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 15
MOLECULAR FORMULA       : C7-H8-Cl-N
MOLECULAR WEIGHT        : 141.61
WISWESSER LINE NOTATION : ZR CG F1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acco Fast Red KB Base
   * 1-Amino-3-chloro-6-methylbenzene
   * 2-Amino-4-chlorotoluene
   * Ansibase Red KB
   * Azoene Fast Red KB Base
   * Azoic Diazo Component 32
   * Benzenamine, 5-chloro-2-methyl-
   * 4-Chloro-2-aminotoluene
   * 3-Chloro-6-methylaniline
   * 5-Chloro-2-methylaniline
   * 5-Chloro-o-toluidine
   * Fast Red KB amine
   * Fast Red KB base
   * Fast Red KB Salt
   * Fast Red KB Salt Supra
   * Fast Red KBS Salt
   * Genazo Red KB Soln
   * Hiltonil Fast Red KB Base
   * Lake Red BK Base
   * Metrogen Red Former KB Soln
   * Naphthosol Fast Red KB Base
   * NCI-C02051
   * Pharmazoid Red KB
   * Red KB Base
   * Spectrolene Red KB
   * Stable Red KB Base
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 464 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
   Science Pub., 1969  Volume(issue)/page/year: 4,113,1969
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - domestic
DOSE/DURATION           : >200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
   Science Pub., 1969  Volume(issue)/page/year: 4,113,1969
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 164 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - adrenal cortex tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-187,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 131 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-187,1979
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 262 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Vascular - tumors
   Liver - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-187,1979
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,157,1995
 
TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 46,305,1977

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-GERMANY;Carcinogen JAN 1993

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NCI Carcinogenesis Bioassay (feed);clear evidence:mouse
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-187,79

   NCI Carcinogenesis Bioassay (feed);inadequate studies:rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-187,79

 
                            *** END OF RECORD ***