m-Cresol, 4,4'-thiobis(6-tert-butyl-

CAS  

 96-69-5

SYNONYMS  

 * Antage Crystal
* Antioxidant AO
* Antioxidant TMB 6
* AO 4
* Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
* Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
* Disperse MB-61
* Nocrac 300
* Nonflex BPS
* Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl-
* Santonox
* Santonox BM
* Santonox R
* Santowhite crystals
* Santox
* Sumilizer WX
* Sumilizer WX-R
* Thioalkofen BM 4
* Thioalkofen BMCH
* Thioalkofen MBCH
* Thioalkophene BM-4
* 4,4'-Thiobis(6-tert-butyl-m-cresol)
* 4,4'-Thiobis(2-tert-butyl-5-methylphenol)
* 4,4'-Thiobis(6-tert-butyl-3-methylphenol)
* 4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
* 4,4'-Thiobis(3-methyl-6-tert-butylphenol)
* 1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)
* USAF B-15
* Yoshinox S
* Yoshinox SR

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : GP3150000
CHEMICAL NAME           : m-Cresol, 4,4'-thiobis(6-tert-butyl-
CAS REGISTRY NUMBER     : 96-69-5
BEILSTEIN REFERENCE NO. : 1147776
REFERENCE               : 4-06-00-06043 (Beilstein Handbook Reference)
LAST UPDATED            : 199712
DATA ITEMS CITED        : 30
MOLECULAR FORMULA       : C22-H30-O2-S
MOLECULAR WEIGHT        : 358.58
WISWESSER LINE NOTATION : 1X1&1&R BQ D1 ESR DQ B1 EX1&1&1
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Antage Crystal
   * Antioxidant AO
   * Antioxidant TMB 6
   * AO 4
   * Bis(3-tert-butyl-4-hydroxy-6-methylphenyl) sulfide
   * Bis(4-hydroxy-5-tert-butyl-2-methylphenyl) sulfide
   * Disperse MB-61
   * Nocrac 300
   * Nonflex BPS
   * Phenol, 4,4'-thiobis(2-(1,1-dimethylethyl)-5-methyl-
   * Santonox
   * Santonox BM
   * Santonox R
   * Santowhite crystals
   * Santox
   * Sumilizer WX
   * Sumilizer WX-R
   * Thioalkofen BM 4
   * Thioalkofen BMCH
   * Thioalkofen MBCH
   * Thioalkophene BM-4
   * 4,4'-Thiobis(6-tert-butyl-m-cresol)
   * 4,4'-Thiobis(2-tert-butyl-5-methylphenol)
   * 4,4'-Thiobis(6-tert-butyl-3-methylphenol)
   * 4,4'-Thiobis(2-(1,1-dimethylethyl)-5-methylphenol)
   * 4,4'-Thiobis(3-methyl-6-tert-butylphenol)
   * 1,1'-Thiobis(2-methyl-4-hydroxy-5-tert-butylbenzene)
   * USAF B-15
   * Yoshinox S
   * Yoshinox SR
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2345 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IPSTB3 International Polymer Science and Technology.  (Rapra Technology
   Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
   3,93,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IPSTB3 International Polymer Science and Technology.  (Rapra Technology
   Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year:
   3,93,1976
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5475 mg/kg/15D-C
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from stomach
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-435,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15015 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Blood - normocytic anemia
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - phosphatases
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-435,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg/14D-I
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in spleen weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
   etc.)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   10,691,1988
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5915 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Endocrine - changes in spleen weight
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-435,1994

                              *** REVIEWS ***
 
   ACGIH TLV-Not classifiable as a human carcinogen
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

   ACGIH TLV-TWA 10 mg/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   OSHA PEL (Gen Indu):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Gen Indu):8H TWA 5 mg/m3, respirable fraction
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Construc):8H TWA 5 mg/m3, respirable fraction
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 15 mg/m3, total dust
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Shipyard):8H TWA 5 mg/m3, respirable fraction
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-FRANCE:TWA 10 mg/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 10 mg/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 10 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL), dust-air:TWA 10 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO 4,4'-THIOBIS(6-t-BUTYL-m-CRESOL)-air:10H TWA 5 mg/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 84755
       No. of Facilities: 4402 (estimated)
       No. of Industries: 51
       No. of Occupations: 47
       No. of Employees: 36695 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 84755
       No. of Facilities: 1286 (estimated)
       No. of Industries: 10
       No. of Occupations: 11
       No. of Employees: 12349 (estimated)
       No. of Female Employees: 2177 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9277;8EHQ-0892-9283
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NTP Carcinogenesis Studies (feed);No evidence:mouse,rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-435,94

 
                            *** END OF RECORD ***