Hydrocinnamic acid,
3-amino-alpha-ethyl-2,4,6-triiodo-

CAS  

 96-83-3

SYNONYMS  

 * 3-Amino-alpha-ethyl-2,4,6-triiodohydrocinnamic acid
* 2-(3-Amino-2,4,6-triiodobenzyl)butyric acid
* 3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid
* beta-(3-Amino-2,4,6-triiodophenyl)-alpha-ethylpropionic acid
* Bilijodon
* Choladine
* Cholevid
* Cistobil
* Colepax
* Copanoic
* 2-Ethyl-3-(3-amino-2,4,6-triiodophenyl)propionic acid
* Iodopanic acid
* Iodopanoic acid
* Iopanoic acid
* Jopagnost
* Telepaque
* Teletrast
* WIN 2011

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : MW5075000
CHEMICAL NAME           : Hydrocinnamic acid,
                          3-amino-alpha-ethyl-2,4,6-triiodo-
CAS REGISTRY NUMBER     : 96-83-3
BEILSTEIN REFERENCE NO. : 2220381
REFERENCE               : 4-14-00-01741 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 10
MOLECULAR FORMULA       : C11-H12-I3-N-O2
MOLECULAR WEIGHT        : 570.94
WISWESSER LINE NOTATION : ZR BI DI FI C1Y2&VQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * 3-Amino-alpha-ethyl-2,4,6-triiodohydrocinnamic acid
   * 2-(3-Amino-2,4,6-triiodobenzyl)butyric acid
   * 3-(3-Amino-2,4,6-triiodophenyl)-2-ethylpropanoic acid
   * beta-(3-Amino-2,4,6-triiodophenyl)-alpha-ethylpropionic acid
   * Bilijodon
   * Choladine
   * Cholevid
   * Cistobil
   * Colepax
   * Copanoic
   * 2-Ethyl-3-(3-amino-2,4,6-triiodophenyl)propionic acid
   * Iodopanic acid
   * Iodopanoic acid
   * Iopanoic acid
   * Jopagnost
   * Telepaque
   * Teletrast
   * WIN 2011
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 86 mg/kg/1W-I
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   ARDEAC Archives of Dermatology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.82-    1960-  Volume(issue)/page/year: 123,387,1987
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 60 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Blood - thrombocytopenia
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   CTOXAO Clinical Toxicology.  (New York, NY)  V.1-18, 1968-81.  For publisher
   information, see JTCTDW.  Volume(issue)/page/year: 18,221,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1540 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,232,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,103,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,232,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,997,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1230 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,103,1990
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 13,997,1970
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2200 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 7,425,1984

                          *** STATUS IN U.S. ***
 
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***