m-Arsanilic acid, N-acetyl-4-hydroxy-

CAS  

 97-44-9

SYNONYMS  

 * 3-Acetamido-4-hydroxybenzenearsonic acid
* 3-Acetamido-4-hydroxy-phenylarsonic acid
* Acetarsol
* Acetarsone
* Acetphenarsine
* 3-Acetylamino-4-hydroxyphenylarsonic acid
* N-Acetyl-4-hydroxy-m-arsanilic acid
* Amarsan
* Amoebal
* Arsaphen
* Arsonic acid, (3-(acetylamino)-4-hydroxyphenyl)-
* Arsonine
* Chrlich 594
* Devegan
* Disparicida
* Dynarsan
* Ehrlich 594
* 190 F
* F 190
* Fourneau 190
* Ginarsol
* Goyl
* Gynoplix
* Kharophen
* Kubarsol
* Limarsol
* Malagride
* Mexyl
* Monargan
* Nilacid
* Oralcid
* Orarsan
* Osarsal
* Osarsol
* Osarsole
* Osvarsan
* Pallicid
* Paroxyl
* Sanogyl
* Spirozid
* Stovarsol
* Stovarsolan
* SVC
* Vagisept
* Vagoflor

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CF8400000
CHEMICAL NAME           : m-Arsanilic acid, N-acetyl-4-hydroxy-
CAS REGISTRY NUMBER     : 97-44-9
BEILSTEIN REFERENCE NO. : 2941984
REFERENCE               : 3-16-00-01132 (Beilstein Handbook Reference)
LAST UPDATED            : 199703
DATA ITEMS CITED        : 34
MOLECULAR FORMULA       : C8-H10-As-N-O5
MOLECULAR WEIGHT        : 275.11
WISWESSER LINE NOTATION : Q-AS-QO&R DQ CMV1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * 3-Acetamido-4-hydroxybenzenearsonic acid
   * 3-Acetamido-4-hydroxy-phenylarsonic acid
   * Acetarsol
   * Acetarsone
   * Acetphenarsine
   * 3-Acetylamino-4-hydroxyphenylarsonic acid
   * N-Acetyl-4-hydroxy-m-arsanilic acid
   * Amarsan
   * Amoebal
   * Arsaphen
   * Arsonic acid, (3-(acetylamino)-4-hydroxyphenyl)-
   * Arsonine
   * Chrlich 594
   * Devegan
   * Disparicida
   * Dynarsan
   * Ehrlich 594
   * 190 F
   * F 190
   * Fourneau 190
   * Ginarsol
   * Goyl
   * Gynoplix
   * Kharophen
   * Kubarsol
   * Limarsol
   * Malagride
   * Mexyl
   * Monargan
   * Nilacid
   * Oralcid
   * Orarsan
   * Osarsal
   * Osarsol
   * Osarsole
   * Osvarsan
   * Pallicid
   * Paroxyl
   * Sanogyl
   * Spirozid
   * Stovarsol
   * Stovarsolan
   * SVC
   * Vagisept
   * Vagoflor
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 86 mg/kg/8D
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   174,819,1927
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 89 mg/kg/9D
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Endocrine - other changes
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   AJMSA9 American Journal of the Medical Sciences.  (Slack Inc., 6900 Grove
   Rd., Thorofare, NJ 08086) New series: V.1-    1841- Volume(issue)/page/year:
   174,819,1927
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 155 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,1282,1961
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1576 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - nausea or vomiting
   Kidney, Ureter, Bladder - urine volume decreased
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,242,1960
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 3,44,1948
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADSYAF Archives of Dermatology and Syphilology.  (Chicago, IL)  V.1-62,
   1920-50.  For publisher information, see ARDEAC.  Volume(issue)/page/year:
   25,799,1932
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03309
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 27,267,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 27,267,1930
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ADSYAF Archives of Dermatology and Syphilology.  (Chicago, IL)  V.1-62,
   1920-50.  For publisher information, see ARDEAC.  Volume(issue)/page/year:
   25,799,1932
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.5 mg(As)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,16,1971

   OSHA PEL (Gen Indu):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.5 mg(As)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.05 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-BELGIUM:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.05 mg(As)/m3 JAN 1993
   
   OEL-FINLAND;Carcinogen JAN 1993
   
   OEL-FRANCE:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-HUNGARY:STEL 0.5 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-INDIA:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.3 mg(As)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.03 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-SWITZERLAND:TWA 0.1 mg(As)/m3;Carcinogen JAN 1993
   
   OEL-THAILAND:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.5 mg(As)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.2 mg(As)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

 
                            *** END OF RECORD ***