MSDS: Leukotriene B4 2/21/02 1:20 PM




MATERIAL SAFETY DATA SHEET
This form complies with OSHA's Hazard Communication Standard, 29 CFR 1910.1200.
IDENTITY (As Used on Label and List): Leukotriene B4


SECTION I - Product Identification
Leukotriene B4


Manufacturer Name and Address: Telephone Numbers:
Cayman Chemical Company Cayman Chemical (800)364-9897
1180 E. Ellsworth Rd.
Ann Arbor, MI. 48108 Cayman Chemical (734)971-3335

Date Entered: 06/27/96 Last Revision: 07/02/98 MSDS Printed: 10/01/99

Synonyms:
6,8,10,14-Eicosatetraenoic acid, 5,12-dihydroxy-,[S-R*,S*-(E,Z,E,Z)]]-

Chemical Family: Leukotriene
Hazard Label:
Molecular Formula: C20H32O4 Molecular Weight: 336.50

NFPA Ratings: (0-4) NFPA Specific Hazards
Health: 2
Flammability: 0
Reactivity: 0




SECTION II - Hazardous Ingredients/Identity Information
Leukotriene B4


Hazardous Components (Specific Chemical Identity/Common Name) CAS #
Leukotriene B4 71160-24-2

CAS # OSHA PEL ACGIH TLV Other Limits Percentage


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71160-24-2 100.0




SECTION III - Physical/Chemical Characteristics
Leukotriene B4

Boiling Point: . . . NE or NA
Melting Point: . . .
Specific Gravity: . . . NE or NA (Water = 1)
Vapor Pressure: . . . NE or NA (mm Hg)
Vapor Density: . . . NE or NA (Air = 1)
Physical States: . . . [ ] Gas , [ X ] Liquid , [ ] Solid
Evaporation Rate: . . . NE or NA (Butyl Acetate = 1)
Solubility In Water: . . . >1 mg/ml* at 25.0C Other: *PBS(pH 7.2), also sol. in EtOH & DMSO
Percent Volatile: . . . NE or NA

Appearance and Odor:
A clear, colorless solution.



SECTION IV - Fire and Explosion Hazard Data
Leukotriene B4

Flash Pt: Method Used: See note below
Explosive Limits: LEL: UEL:

Extinguishing Media:
Use alcohol foam, carbon dioxide, or water spray when fighting fires involving this material.

Special Fire Fighting Procedures:
Note: Flammable as diluted in ethanol.

Unusual Fire and Explosion Hazards:



SECTION V - Reactivity Data
Leukotriene B4

Stability: Unstable [ ] Stable [ X ]

Conditions To Avoid - Instability:

Incompatibility - Materials To Avoid:

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Hazardous Decomposition Or Byproducts:

Hazardous Polymerization: May occur [ ] Will not occur [ X ]

Conditions To Avoid - Hazardous Polymerization:



SECTION VI - Health Hazard Data
Leukotriene B4

Route(s) of Entry: Inhalation? Yes , Skin? Yes , Eyes? Yes , Ingestion? Yes
Other:

Health Hazards (Acute and Chronic):
Contact may cause skin or eye irritation. Stimulates smooth muscle contracion. May cause intense
bronchospasm (particularly in asthmatic patients). May cause gastrointestinal disturbances. The acute
effects of overexposure may include dizziness, hypotension, flushing, irritation, and nausea.

Carcinogenicity: NTP? , IARC Monographs? , OSHA Regulated?

Carcinogenicity/Other Information:

Recommended Exposure Limits:
LD 50/LC 50:

Signs and Symptoms Of Exposure:
Irritating to the nose, throat and respiratory tract.

Medical Conditions Generally Aggravated By Exposure:
Asthma

Emergency and First Aid Procedures:
If inhaled remove to fresh air. If not breathing, give artificial respiration or give oxygen by trained
personnel. Get immediate medical attention. If swallowed, wash out mouth with water provided person is
conscious. Never give anything by mouth to an unconscious person. Get medical attention. In case of
contact with eyes, hold eyelids apart and flush eyes with plenty of water. After initial flushings, remove any
contact lenses and continue flushing for at least 15 minutes. Have eyes examined and tested by medical
personnel. In case of skin contact, immediately wash skin with soap and plenty of water. Remove
contaminated clothing. Get medical attention if symptoms occur. Wash clothing before reuse.



SECTION VII - Precautions for Safe Handling and Use
Leukotriene B4


Steps To Be Taken In Case Material Is Released Or Spilled:
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Absorb the liquid and scrub the area with detergent and water.

Waste Disposal Method:
Dispose in accordance with local, state and federal regulations.

Hazard Label Information: Avoid contact with skin and eyes. Do not reuse this container. Use with
adequate ventilation. Wash thoroughly after handling.

Precautions To Be Taken in Handling and Storing:
Avoid contact with eyes, skin, and clothing. Do not reuse this container. Use with adequate ventilation.
Wash thoroughly after handling.

Other Precautions:



SECTION VIII- Control Measures
Leukotriene B4

Protective Equipment Summary - Hazard Label Information Eye wash station in work area Lab coat Latex
disposable gloves Safety glasses Safety shower in work area Vent Hood

Respiratory Equipment (Specify Type):

Ventilation:
Good general ventilation should be sufficient to control airborne levels.

Eye Protection:
Safety glasses

Protective Gloves:
Latex disposable gloves

Other Protective Clothing:
Lab coat

Work/Hygienic/Maintenance Practices:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower.
Wash thoroughly after handling.



SECTION IX - Additional Comments
Leukotriene B4


For research use only, not for human or veterinary clinical use.

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For research use only, not for human or veterinary clinical use. DISCLAIMER:
This information is believed to be accurate and represents the best information currently available to us.
However, we make no warranty of merchantability or any other warranty, express or implied, with respect
to such information, and we assume no liability resulting from its use. Users should make their own
investigations to determine the suitability of the information for their particular purposes.




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LEUKOTRIENE B4