*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QD1035000
CHEMICAL NAME : Morphinan-6-ol,
7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-,
(5-alpha,6-alpha)-, mixed with
gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropana
mine (Z)-2- butenedioate (1:1)
CAS REGISTRY NUMBER : 76095-56-2
LAST UPDATED : 199706
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C18-H21-N-O3.C16-H19-Cl-N2.C4-H4-O4
MOLECULAR WEIGHT : 690.30
COMPOUND DESCRIPTOR : Drug
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >40 mL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Kidney, Ureter, Bladder - hematuria
Endocrine - other changes
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,797,1988
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >40 mL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Endocrine - other changes
Skin and Appendages - hair
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,797,1988
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 900 mL/kg/90D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
Blood - changes in erythrocyte (RBC) count
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 16,805,1988
*** END OF RECORD ***
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