*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QI9277520
CHEMICAL NAME : 2-Naphthacenecarboxamide,
1,4,4a,5,12,12a-hexahydro-4-(dimethylamino)-1,12-diox
o-6-methyl- 3,10,11,12a-tetrahydroxy-,
(4S-(4-alpha,4a-alpha,12a-alpha))-
CAS REGISTRY NUMBER : 1665-56-1
LAST UPDATED : 199009
DATA ITEMS CITED : 6
MOLECULAR FORMULA : C22-H22-N2-O7
MOLECULAR WEIGHT : 426.46
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* Anhydrotetracycline
* (4S)-Anhydrotetracycline
* 5a,6-Anhydrotetracycline
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 134 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YHHPAL Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal.
(China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
China) V.1- 1953- Suspended 1966-78. Volume(issue)/page/year:
13,244,1966
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 34 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
In New Drugs, Proceedings of the Symposium on Toxicological Testing for
Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
Czechoslovakia, Univerzita Karlova, 1979 Volume(issue)/page/year: -,55,1979
** MUTATION DATA **
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 20 mg/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
518,267,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 20 mg/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
518,267,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 10 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 20 mg/L
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
Switzerland) V.1- 1945- Volume(issue)/page/year: 30,403,1974
*** END OF RECORD ***
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(2Z,4S,4aS,12aS)-2-(amino-hydroxy-methylidene)-4-dimethylamino-10,11,1 2a-trihydroxy-6-methyl-4a,5-dihydro-4H-tetracene-1,3,12-trione