Conforms to 93/112/EC and ISO 11014-1

SAFETY DATA SHEET
Order Customer
Number
Number

Identification of the substance/preparation and of the company/undertaking
1.
Australine, Hydrochloride,
Castanospermum australe : 189422
Product name : Catalog #
: Manufactured by EMD Biosciences, Inc.
Supplier
10394 Pacific Center Court
.
Chemical formula C8H15NO4 HCl
:
San Diego, CA 92121
(858)450-5558/(800)854-3417
FAX: (858)453-3552

Australine, Hydrochloride
:
Synonym




Emergency : Call Chemtrec?
telephone number (800)424-9300 (within U.S.A.)
(703)527-3887 (outside U.S.A.)

Composition / information on ingredients
2.
: Substance
Substance/Preparation

Chemical name* CAS No. EC Number Symbol R-Phrases
1) 186766-07-4 Not available. Xi R36/37/38
(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrol


Hazards identification
3.
: Not applicable.
Physical/chemical hazards
: CAUTION!
Human health hazards
MAY CAUSE RESPIRATORY TRACT, EYE AND SKIN IRRITATION.



First-aid measures
4.
First-Aid measures
: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Inhalation
Get medical attention.
: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
Ingestion
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
: In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient.
Skin Contact
Remove contaminated clothing and shoes. Cold water may be used.Wash clothing before reuse. Thoroughly
clean shoes before reuse. Get medical attention.
: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
Eye Contact
least 15 minutes. Cold water may be used. Get medical attention.

Effects and symptoms
Inhalation : Hazardous in case of inhalation (lung irritant).
: Hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening,
Skin Contact
or, occasionally, blistering.
: Hazardous in case of eye contact (irritant).
Eye Contact
: Repeated or prolonged exposure is not known to aggravate medical condition.
Aggravating conditions




189422
Catalog #
 5. Fire-fighting measures
: May be combustible at high temperature.
Flammability of the Product
Extinguishing Media
: SMALL FIRE: Use DRY chemical powder.
Suitable
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Hazardous thermal (de)composition : These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
products
: Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Special fire-fighting procedures
: Be sure to use an approved/certified respirator or equivalent.
Protection of fire-fighters

Accidental release measures
6.
: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be
Personal precautions
used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
: Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
Small Spill and Leak
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
: Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
Large Spill and Leak
water on the contaminated surface and allow to evacuate through the sanitary system

Handling and storage
7.
: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
Handling
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable
protective clothing. If you feel unwell, seek medical attention and show the label when possible. Avoid contact
with skin and eyes.
: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 4??C (39.2??F).
Storage
Packaging materials
: Use original container.
Recommended use


Exposure controls/personal protection
8.
: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering measures
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure
to airborne contaminants below the exposure limit.
: Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.
Hygiene measures
Ingredient Name Occupational Exposure Limits
1) Australine, Hydrochloride, Castanospermum Not available.
australe

Personal protective equipment
: Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Respiratory system
: Lab coat.
Skin and body
: Gloves.
Hands
: Splash goggles.
Eyes
:
Protective Clothing
(Pictograms)




Physical and chemical properties
9.
: Solid. (Crystalline solid.)
Physical state
Color : Not available.
: 225.7 g/mole
Molecular Weight
: Easily soluble in cold water, methanol.
Solubility
Flash point : Not available.
: Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive properties
Risks of explosion of the product in presence of static discharge: Not available.




189422
Catalog #
 10. Stability and reactivity
: The product is stable.
Stability
: Not available.
Conditions to avoid
: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
Hazardous Decomposition Products


11. Toxicological information
:
RTECS # Not available.
Local effects
Skin irritation : Hazardous in case of skin contact (irritant).
: LD50: Not available.
Acute toxicity
LC50: Not available.
: Repeated or prolonged exposure is not known to aggravate medical condition.
Chronic toxicity
: Not available.
Other Toxic Effects on
Humans Hazardous in case of skin contact (irritant), of inhalation (lung irritant).

Not available.

Material is irritating to mucous membranes and upper respiratory tract. To the best of our knowledge, the
toxicological properties of this product have not been thoroughly investigated.

Carcinogenic effects : Not available.
: Not available.
Mutagenic effects
Reproduction toxicity : Not available.
: Not available.
Teratogenic effects

12. Ecological information
: Not available.
Ecotoxicity
: The product itself and its products of degradation are not toxic.
Toxicity of the Products of
Biodegradation

13. Disposal considerations
: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Methods of disposal; Waste of
residues; Contaminated packaging


14. Transport information
International transport regulations
Land - Road/Railway
: Not controlled under ADR (Europe).
ADR/RID Class
Sea
: Not controlled under IMDG.
IMDG Class
Air
: Not controlled under IATA.
IATA-DGR Class
Not applicable.
Special Provisions for
Transport

15. Regulatory information
EU Regulations
Hazard symbol(s) :




: Irritant
Classification
: R36/37/38- Irritating to eyes, respiratory system and skin.
Risk Phrases
: S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Safety Phrases
S36- Wear suitable protective clothing.
: TSCA: No products were found.
U.S. Federal Regulations

189422
Catalog #
 SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.
Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
: CLASS: Irritating substance.
HCS Classification
:
State Regulations


: Not controlled under WHMIS (Canada).
WHMIS (Canada)
No products were found.


16. Other information
Hazardous Material 2 National Fire
Health
Fire Hazard
1
Information System 1 Protection
Fire Hazard
(U.S.A.) Association (U.S.A.) 2 0
Health Reactivity
0
Reactivity
Specific Hazard
E
Personal Protection


Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its
subsidiaries assumes any liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be
used with caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist.
Date of issue
3/13/2003.
189422
Catalog #


AUSTRALINE HYDROCHLORIDE