Conforms to 93/112/EC and ISO 11014-1


SAFETY DATA SHEET
Order Number Customer Number


Identification of the substance/preparation and of the company/undertaking
1.
Product name MMP-2/MMP-3 Inhibitor III, PD166793 : 444284
: Catalog #
: EMD Biosciences, Inc.
Supplier
10394 Pacific Center Court
Chemical formula C17C18BrNO4S
: San Diego, CA 92121
(858)450-5558/(800)854-3417
FAX: (858)453-3552

(S)-2-(4' -Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
Synonym :



This product is being sent to you as Research and Development
product as defined by the Toxic Substances Act (TSCA) of 1976. Due
to TSCA??s R&D exemption, this product is not listed on the U.S. EPA??s
Toxic Substances Control Act (TSCA??s) inventory. As a TSCA-exempt
R&D substance, this product must be used by or directly under the
supervision of a technically qualified individual(s) as defined by TSCA.
This product may not be used for commercial purposes or in
formulations used for commercial purposes.



Emergency telephone : Call Chemtrec?
number (800)424-9300 (within U.S.A.)
(703)527-3887 (outside U.S.A.)


Composition / information on ingredients
2.
: Substance
Substance/Preparation

Chemical name* CAS No. EC Number Symbol R-Phrases
(S)-2-(4' -Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid) 199850-67-4 Not available. Xi R36/37/38



Hazards identification
3.
: Not applicable.
Physical/chemical hazards
: WARNING!
Human health hazards
CAUSES RESPIRATORY TRACT, EYE AND SKIN IRRITATION.



First-aid measures
4.
First-Aid measures
: If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical
Inhalation
attention immediately.
: Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious
Ingestion
person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a
collar, tie, belt or waistband.
: In case of contact, immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing
Skin Contact
and shoes. Cover the irritated skin with an emollient. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Get medical attention immediately.
: Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
Eye Contact
minutes. Get medical attention immediately.

Effects and symptoms
Inhalation : Very hazardous in case of inhalation (lung irritant).
: Very hazardous in case of skin contact (irritant). Skin inflammation is characterized by itching, scaling, reddening, or,
Skin Contact
occasionally, blistering.
: Very hazardous in case of eye contact (irritant). Inflammation of the eye is characterized by redness, watering, and itching
Eye Contact
: Repeated or prolonged exposure is not known to aggravate medical condition.
Aggravating conditions




444284
Catalog #
5. Fire-fighting measures
: May be combustible at high temperature.
Flammability of the Product
Extinguishing Media
: SMALL FIRE: Use DRY chemical powder.
Suitable
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...), halogenated
Hazardous thermal (de)composition
compounds.
products

: Fire fighters should wear positive pressure self-contained breathing apparatus (SCBA) and full turnout gear.
Special fire-fighting procedures
: Be sure to use an approved/certified respirator or equivalent.
Protection of fire-fighters


Accidental release measures
6.
: Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self-contained breathing apparatus should be used to avoid
Personal precautions
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
product.
: Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Small Spill and Leak


: Use a shovel to put the material into a convenient waste disposal container.
Large Spill and Leak



Handling and storage
7.
: Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the residue under
Handling
a fume hood. Ground all equipment containing material. Do not breathe dust. If you feel unwell, seek medical attention and
show the label when possible. Avoid contact with skin and eyes.
: Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 4??C (39.2??F).
Storage
Packaging materials
: Use original container.
Recommended use


Exposure controls/personal protection
8.
: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
Engineering measures
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne
contaminants below the exposure limit.
: Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.
Hygiene measures
Ingredient Name Occupational Exposure Limits
MMP-2/MMP-3 Inhibitor III, PD166793 Not available.


Personal protective equipment
: Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation
Respiratory system
is inadequate.
: Lab coat.
Skin and body
: Gloves.
Hands
: Splash goggles.
Eyes
Protective Clothing (Pictograms) :




Physical and chemical properties
9.
: Solid.
Physical state
Color : Off-white.
: 412.3 g/mole
Molecular Weight

: 194??C (381.2??F)
Melting Point
: Not available.
Solubility
Flash point : Not available.
: Risks of explosion of the product in presence of mechanical impact: Not available.
Explosive properties
Risks of explosion of the product in presence of static discharge: Not available.




444284
Catalog #
 10. Stability and reactivity
: The product is stable.
Stability
: Not available.
Conditions to avoid
: These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...), halogenated
Hazardous Decomposition Products
compounds.


11. Toxicological information
RTECS # : Not available.
Local effects
Skin irritation : Very hazardous in case of skin contact (irritant).
: LD50: Not available.
Acute toxicity
LC50: Not available.
: Repeated or prolonged exposure is not known to aggravate medical condition.
Chronic toxicity
: Not available.
Other Toxic Effects on Humans
Very hazardous in case of skin contact (irritant), of eye contact (irritant), of inhalation (lung irritant)

Not available.

To the best of our knowledge, the toxicological properties of this product have not been thoroughly investigated.


Carcinogenic effects : Not available.
: Not available.
Mutagenic effects
Reproduction toxicity : Not available.
: Not available.
Teratogenic effects


12. Ecological information
: Not available.
Ecotoxicity
: The product itself and its products of degradation are not toxic.
Toxicity of the Products of
Biodegradation


13. Disposal considerations
: Waste must be disposed of in accordance with federal, state and local environmental control regulations.
Methods of disposal; Waste of residues;
Contaminated packaging



14. Transport information
International transport regulations
Land - Road/Railway
: Not controlled under ADR (Europe).
ADR/RID Class
Sea
: Not controlled under IMDG.
IMDG Class
Air
: Not controlled under IATA.
IATA-DGR Class
Not applicable.
Special Provisions for
Transport


15. Regulatory information
EU Regulations
Hazard symbol(s) :




: Irritant
Classification
: R36/37/38- Irritating to eyes, respiratory system and skin.
Risk Phrases
: S26- In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Safety Phrases
S36- Wear suitable protective clothing.
U.S. Federal Regulations : TSCA: No products were found.
SARA 302/304/311/312 extremely hazardous substances: No products were found.
SARA 302/304 emergency planning and notification: No products were found.
SARA 302/304/311/312 hazardous chemicals: No products were found.
SARA 311/312 MSDS distribution - chemical inventory - hazard identification: No products were found.
SARA 313 toxic chemical notification and release reporting: No products were found.

444284
Catalog #
 Clean Water Act (CWA) 307: No products were found.
Clean Water Act (CWA) 311: No products were found.
Clean air act (CAA) 112 accidental release prevention: No products were found.
Clean air act (CAA) 112 regulated flammable substances: No products were found.
Clean air act (CAA) 112 regulated toxic substances: No products were found.
: CLASS: Irritating substance.
HCS Classification

State Regulations :


: CLASS D-2B: Material causing other toxic effects (TOXIC).
WHMIS (Canada)

No products were found.


16. Other information
Hazardous Material 2 National Fire
Health
Fire Hazard
1
Information System Protection Association
1
Fire Hazard
(U.S.A.) (U.S.A.) 2 0
Health Reactivity
0
Reactivity
Specific Hazard
E
Personal Protection
Personal Protection


Notice to Reader
To the best of our knowledge, the information contained herein is accurate. However, neither the above named supplier nor any of its subsidiaries assumes any
liability whatsoever for the accuracy or completeness of the information contained herein.
Final determination of suitability of any material is the sole responsibility of the user. All materials may present unknown hazards and should be used with
caution. Although certain hazards are described herein, we cannot guarantee that these are the only hazards that exist. **This product is intended for research
use only.**

444284
Catalog # Date of issue 10/23/2006.


PD 166793