*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QD3181000
CHEMICAL NAME : Morphinan-3,6-alpha,14-triol,
17-(cyclobutylmethyl)-4,5-alpha-epoxy-, hydrochloride
CAS REGISTRY NUMBER : 23277-43-2
LAST UPDATED : 199504
DATA ITEMS CITED : 5
MOLECULAR FORMULA : C21-H27-N-O4.Cl-H
MOLECULAR WEIGHT : 393.95
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* 17-Cyclobutylmethyl-4,5-alpha-epoxymorphinan-3,6-alpha,14-triol
hydrochloride
* N-Cyclobutylmethyl-14-hydroxydihydronormorphine hydrochloride
* En 2234A
* Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, hydrochloride,
(5-alpha,6-alpha)-
* Nalbufina clorhidrato
* Nalbuphine hydrochloride
* Nubain
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 800 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
REFERENCE :
CHETBF Chest. (American College of Chest Physicians, 911 Busse Hwy, Park
Ridge, IL 60068) V.57- 1970- Volume(issue)/page/year: 90,773,1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
16,51,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
16,51,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 140 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
16,51,1980
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X5314
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 628 (estimated)
No. of Female Employees: 314 (estimated)
*** END OF RECORD ***
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NALBUPHINE HYDROCHLORIDE