Pyridine,3-[(2R)-1-methyl-2-pyrrolidinyl]- MSDS CasNo.25162-00-9

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CAS : 25162-00-9

MSDS	:	2'-beta-H-Nicotine
CAS	:	25162-00-9
SYNONYMS	:	* (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine * (+)-Nicotine * d-Nicotine * D-Nicotine * Pseudonicotine * Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (R)-

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[ 2'-beta-H-Nicotine 25162-00-9 ]

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QS5260000
CHEMICAL NAME           : 2'-beta-H-Nicotine
CAS REGISTRY NUMBER     : 25162-00-9
OTHER CAS REGISTRY NOS. : 1596-94-7
BEILSTEIN REFERENCE NO. : 4666243
REFERENCE               : 5-23-06-00064 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C10-H14-N2
MOLECULAR WEIGHT        : 162.26
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (R)-3-(1-Methyl-2-pyrrolidinyl)pyridine
   * (+)-Nicotine
   * d-Nicotine
   * D-Nicotine
   * Pseudonicotine
   * Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (R)-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,584,1948
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6150 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   84,1,1984
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Vascular - BP elevation not characterized in autonomic section
REFERENCE :
   85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme
   Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948
    Volume(issue)/page/year: -,584,1948
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - domestic
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHZOA9 Physiological Zoology.  (Univ. of Chicago Press, Journals Div., POB
   37005, Chicago, IL 60637) V.1-    1928-  Volume(issue)/page/year:
   12,238,1939
 
                            *** END OF RECORD ***

(+)-NICOTINE-(+)-DI-P-TOLUOYL TARTRATE S YNTHETIC >99%