Threitol, 1,4-dithio-, DL-

CAS  

 27565-41-9

SYNONYMS  

 * 2,3-Butanediol, 1,4-dimercapto-, DL-threo-
* 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)- (+-)-
* Cleland's reagent
* DL-threo-1,4-Dimercapto-2,3-butanediol
* (R*,R*)-(+-)-1,4-Dimercapto-2,3-butanediol
* Dithiothreitol
* DL-Dithiothreitol
* DL-1,4-Dithiothreitol
* rac-Dithiothreitol

                     *** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : XO8576500
CHEMICAL NAME           : Threitol, 1,4-dithio-, DL-
CAS REGISTRY NUMBER     : 27565-41-9
BEILSTEIN REFERENCE NO. : 1719757
REFERENCE               : 3-01-00-02360 (Beilstein Handbook Reference)
LAST UPDATED            : 199806
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C4-H10-O2-S2
MOLECULAR WEIGHT        : 154.26
WISWESSER LINE NOTATION : SH1YQYQ1SH -DL, THREO
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * 2,3-Butanediol, 1,4-dimercapto-, DL-threo-
   * 2,3-Butanediol, 1,4-dimercapto-, (R*,R*)- (+-)-
   * Cleland's reagent
   * DL-threo-1,4-Dimercapto-2,3-butanediol
   * (R*,R*)-(+-)-1,4-Dimercapto-2,3-butanediol
   * Dithiothreitol
   * DL-Dithiothreitol
   * DL-1,4-Dithiothreitol
   * rac-Dithiothreitol
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 169 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,600,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 333 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,1434,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 94 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 22,1434,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ABCHA6 Agricultural and Biological Chemistry.  (Maruzen Co. Ltd., POB 5050,
   Tokyo International, Tokyo 100-31, Japan)  V.25-    1961-
   Volume(issue)/page/year: 45,327,1981
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 77,1150,1977
 
TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Non-mammalian species Embryo
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   JCLBA3 Journal of Cell Biology.  (Rockefeller Univ. Press, 1230 York Ave.,
   New York, NY 10003) V.12-    1962-  Volume(issue)/page/year: 60,497,1974
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   ABBIA4 Archives of Biochemistry and Biophysics.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802)  V.31-    1951-  Volume(issue)/page/year:
   166,400,1975

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X2950
       No. of Facilities: 35 (estimated)
       No. of Industries: 1
       No. of Occupations: 3
       No. of Employees: 627 (estimated)
       No. of Female Employees: 436 (estimated)

 
                            *** END OF RECORD ***