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Name	o-ACETYLSALICYLIC ACID, SODIUM SALT	EINECS	N/A
CAS No.	493-53-8	Density	g/cm³
PSA	66.43000	LogP	-0.02460
Solubility	N/A	Melting Point	218 °C
Formula	C9H8 O4 . Na	Boiling Point	321.4°Cat760mmHg
Molecular Weight	202.142	Flash Point	131.2°C
Transport Information	N/A	Appearance	N/A
Safety	Moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na₂O. See also ACETOL.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	Benzoicacid, 2-(acetyloxy)-, sodium salt (9CI); Salicylic acid acetate, sodium salt(8CI); Acetylsalicylate sodium; Acetylsalicylic acid, sodium salt; Aspirinsodium salt; Sodium acetylsalicylate; Sodium acetylsalicylic acid; Sodiumaspirin; Sodium o-acetoxybenzoate; Sodium o-acetyloxybenzoate; Sodiumsalicylate (NaO3C7H5), acetate	Article Data	9

o-ACETYLSALICYLIC ACID, SODIUM SALT Synthetic route

: 50-78-2
aspirin

: 493-53-8
sodium O-acetylsalicylate

Conditions

Conditions	Yield
With sodium hydrogencarbonate In water; isopropyl alcohol at 20℃; for 3h;	88%
With sodium hydride In N,N-dimethyl-formamide for 0.5h;
With sodium carbonate

: 50-78-2
aspirin

sodium bi carbonate: sodium bi carbonate

: 493-53-8
sodium O-acetylsalicylate

Conditions

Conditions	Yield
With water

: 50-78-2
aspirin

sodium carbonate: sodium carbonate

: 493-53-8
sodium O-acetylsalicylate

Conditions

Conditions	Yield
With acetic acid ester
With methanol
With methanol
With acetic acid ester

: acetylsalicylic acid sodium salt

CuCl2 dihydrate: CuCl2 dihydrate

: 50-78-2
aspirin

: 493-53-8
sodium O-acetylsalicylate

Conditions

Conditions	Yield
With sodium hydroxide In water
With sodium hydroxide In water

: Ti(4+)*2OH(1-)*SO4(2-)=Ti(OH)2SO4

: 493-53-8
sodium O-acetylsalicylate

: 294868-46-5
(OH)2Ti(IV)(acetylsalicylate)2

Conditions

Conditions	Yield
	92%

: 127-09-3
sodium acetate

: 493-53-8
sodium O-acetylsalicylate

: 2-dipropylaminoethyl acetylsalicylate acetate

Conditions

Conditions	Yield
Stage #1: 3-diethylamino-propyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform for 0.5h; Stage #2: sodium acetate In chloroform for 2h; Product distribution / selectivity;	81.6%

: 127-09-3
sodium acetate

: 22511-39-3
2-dipropylaminoethyl bromide hydrobromide

: 493-53-8
sodium O-acetylsalicylate

: 2-dipropylaminoethyl acetylsalicylate acetate

Conditions

Conditions	Yield
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform for 2h;	81.6%
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform for 2h;	81.6%
Stage #1: 2-dipropylaminoethyl bromide hydrobromide; sodium O-acetylsalicylate In chloroform at 20℃; for 5h; Stage #2: sodium acetate In chloroform at 20℃; for 2h;

: 52462-29-0
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2

: 493-53-8
sodium O-acetylsalicylate

: [RuCl(κ2O-aspCO2)(η6-p-cymene)]

Conditions

Conditions	Yield
In methanol at 20℃; for 2.5h; Schlenk technique; Inert atmosphere;	79%

: 1271-19-8
bis(cyclopentadienyl)titanium dichloride

: 493-53-8
sodium O-acetylsalicylate

: (η(5)-cyclopentadienyl)2Ti(IV)(acetylsalicylate)2

Conditions

Conditions	Yield
In benzene Na salt and Ti complex refluxed in benzene for 15 h; cooled to room temp., filtered, filtrate concd. in vac., petroleum ether added, placed in refrigerator overnight, filtered, dried in vac. desiccator over P4O10 for 30 h, elem. anal.;	78%
In benzene a mixt. of (η-C5H5)2TiCl2 and Na salt of the substituted benzoic acid in anhydrous benzene stirred at 30°C for 4 h; orange soln. filtered, concd., crystn. (refrigerator), recrystd. (benzene);	7%
In not given

: 683-18-1
dibutyltin chloride

: 493-53-8
sodium O-acetylsalicylate

: nBu2Sn(acetylsalicylic acid(-H))2

Conditions

Conditions	Yield
In ethanol Reflux;	74%

o-ACETYLSALICYLIC ACID, SODIUM SALT Chemical Properties

O-acetylsalicylic acid, sodium salt has some synonyms like sodium O-acetylsalicylate;2-(Acetyloxy)benzoic acid sodium salt;2-Acetyloxybenzoic acid sodium salt,etc.

Molecular Formula: C₉H₇NaO₄
Molecular Weight: 202.13925
EINECS: 207-777-7

o-ACETYLSALICYLIC ACID, SODIUM SALT Toxicity Data With Reference

1.	ivn-hmn TDLo:306 µg/kg:BLD	GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent Office, Science Library, 2021 Jefferson Davis Highway, Arlington, VA 22202) #2810425 .
2.	ipr-rat LD50:1450 mg/kg	NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 79 (1982),357.
3.	scu-mus LDLo:700 mg/kg	HDTU** Pharmakologische Prufung von Analgetika, Gunter Herrlen Dissertation. (Pharmakologischen Institut der Universitat Tubingen, Germany, 1933)1933.
4.	ipr-mus LDLo:500 mg/kg	JACSAT Journal of the American Chemical Society. 63 (1941),1437.
5.	scu-frg LDLo:909 mg/kg	HBAMAK Abdernalden’s Handbuch der Biologischen Arbeitsmethoden. 4 (1935),1290.

o-ACETYLSALICYLIC ACID, SODIUM SALT Safety Profile

O-acetylsalicylic acid, sodium salt was moderately toxic by intraperitoneal and subcutaneous routes. Human systemic effects by intravenous route: unspecified changes in the blood. When heated to decomposition it emits toxic fumes of Na₂O. See also ACETOL.

o-ACETYLSALICYLIC ACID, SODIUM SALT Specification

Storage and transport characteristics:storage house needs to be ventilated ,at low-temperature and dry;O-acetylsalicylic acid, sodium salt are kept separately with oxidants, acids, food chemical additives.

Extinguishing agent:
Water mist, foam, carbon dioxide, sand

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