Clemizole CAS NO.442-52-4

clemizole is a h1 histamine receptor antagonist.recently, researchers have identified that clemizole hydrochloride can inhibit ns4b's rna binding and hepatitis c virus (hcv) replication.
ic50 value: 8 mm (ns4b) [1]
target: h1 receptor; anti-hcv
in vitro: although significant, clemizole's antiviral effect is moderate (50% effective concentration of 8 microm against an hcv genotype 2a clone). combinations of clemizole with either interferon, ribavirin, or the nucleoside (nm283) and nonnucleoside (hcv796) hcv polymerase inhibitors were additive [1]. the differences in the rodent and human pathways for clemizole metabolism were of importance, because the predominant human metabolite was found to have synergistic anti-hcv activity [2].
in vivo: clemizole and reserpine treatment did not produce any modification of the dose-response curve to histamine [3].
clinical trial: safety and tolerability study of clemizole hydrochloride to treat hepatitis c in subjects who are treatment-naive (clean-1). nct00945880. phase 1