USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $1.00-1.00 / Kilogram
dapt basic information |
product name: | dapt |
synonyms: | ly-374973, n-[n-(3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester;γ-secretase inhibitor ix;n-[(3,5-difluorophenyl)acetyl]-l-alanyl-2-phenyl]glycine-1,1-dimethylethylester;sc-201315;(2s)-n-[n-(3,5-difluorophenacetyl)-l-alanyl]-2-phenylglycine tert-butyl ester;dapt (enzyme inhibitor);gsi-ix;dapt (gsi-ix) |
cas: | 208255-80-5 |
mf: | c23h26f2n2o4 |
mw: | 432.464 |
einecs: | |
product categories: | angiogenesis and metastasis;protease inhibitor;inhibitor;gsi-ix;inhibitors |
mol file: | 208255-80-5.mol |
dapt chemical properties |
density | 1.213 |
storage temp. | 2-8°c |
solubility | dmso: ~18 mg/ml |
form | solid |
color | white |
safety information |
wgk germany | 3 |
dapt usage and synthesis |
usage | dapt (gsi-ix) is a novel γ-secretase inhibitor, which inhibits aβ production with ic50 of 20 nm in hek 293 cells |
biological activity | inhibitor of γ -secretase; causes a reduction in a β 40 and a β 42 levels in human primary neuronal cultures (ic 50 values are 115 and 200 nm for total a β and a β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . does not effect app α and app β levels. blocks notch signaling in hybrid human-mouse foetal thymus organ culture (ftoc). activity causes neural cells to commit to neuronal differentiation. |
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