DAPT CAS NO.208255-80-5

Min.Order Quantity:: 1 Metric Ton

Purity:: 99%

Port:: shanghai

Payment Terms:: L/C,T/T

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Product Details

Keywords

208255-80-5
DAPT
208255-80-5

Quick Details

ProName: DAPT
CasNo: 208255-80-5
Molecular Formula: 208255-80-5
Appearance: solid
Application: intermediate
DeliveryTime: prompt
PackAge: as per buyers
Port: shanghai
ProductionCapacity: 10 Metric Ton/Day
Purity: 99%
Storage: R.T.
Transportation: by air/sea
LimitNum: 1 Metric Ton
Grade: Industrial Grade,Food Grade,Pharma Gra...

Superiority

good quantity

dapt basic information

product name:	dapt
synonyms:	ly-374973, n-[n-(3,5-difluorophenacetyl)-l-alanyl]-s-phenylglycine t-butyl ester;γ-secretase inhibitor ix;n-[(3,5-difluorophenyl)acetyl]-l-alanyl-2-phenyl]glycine-1,1-dimethylethylester;sc-201315;(2s)-n-[n-(3,5-difluorophenacetyl)-l-alanyl]-2-phenylglycine tert-butyl ester;dapt (enzyme inhibitor);gsi-ix;dapt (gsi-ix)
cas:	208255-80-5
mf:	c23h26f2n2o4
mw:	432.464
einecs:
product categories:	angiogenesis and metastasis;protease inhibitor;inhibitor;gsi-ix;inhibitors
mol file:	208255-80-5.mol

Details

dapt chemical properties

density	1.213
storage temp.	2-8°c
solubility	dmso: ~18 mg/ml
form	solid
color	white

safety information

wgk germany

msds information

dapt usage and synthesis

usage

dapt (gsi-ix) is a novel γ-secretase inhibitor, which inhibits aβ production with ic50 of 20 nm in hek 293 cells

biological activity

inhibitor of γ -secretase; causes a reduction in a β 40 and a β 42 levels in human primary neuronal cultures (ic 50 values are 115 and 200 nm for total a β and a β 42 respectively) and in brain extract, cerebrospinal fluid and plasma in vivo . does not effect app α and app β levels. blocks notch signaling in hybrid human-mouse foetal thymus organ culture (ftoc). activity causes neural cells to commit to neuronal differentiation

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