Granisetron 109889-09-0 CAS NO.109889-09-0

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Min.Order Quantity:: 1 Kilogram

Purity:: 99%min

Port:: Zhengzhou,Tianjin

Payment Terms:: L/C,D/A,D/P,T/T,

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Product Details

Keywords

109889-09-0
Granisetron
granisetron hydrochloride

Quick Details

ProName: Granisetron 109889-09-0
CasNo: 109889-09-0
Molecular Formula: C18H24N4O
Appearance: White or almost white powder
Application: Central Nervous System Drug; Anti-Emet...
DeliveryTime: 10days
PackAge: 25Kg/Drum
Port: Zhengzhou,Tianjin
ProductionCapacity: 2000 Kilogram/Week
Purity: 99%min
Storage: Stored in a cool and dry well-closed ...
Transportation: by sea,air
LimitNum: 1 Kilogram
Related Substances: Conforms
Residue on Ignition: Conforms
Heavy Metal: ≤10ppm
Valid Period: Two years when properly stored.
Molecular weight: 312.41

Superiority

granisetron is a serotonin 5-ht3 receptor antagonist used as an antiemetic to treat nausea and vomiting followingchemotherapy. its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. it does not have much effect on vomiting due to motion sickness. this drug does not have any effect on dopamine receptors or muscarinic receptors.
granisetron was developed by chemists working at the british drug company beecham around 1988 and is available as a generic. it is produced by roche laboratories under the trade name kytril. the drug was approved in the united kingdomin 1991 and in united states in 1994 by the fda.
a granisetron transdermal patch with the trade name sancuso was approved by the us fda on september 12, 2008.[1] sancuso is manufactured by prostrakan, inc., a pharmaceutical company headquartered in bedminster, nj, with global headquarters in scotland.
granisetron is metabolized slowly by the liver, giving it a longer than average half-life. one dose usually lasts 4 to 9 hours and is usually administered once or twice daily. this drug is removed from the body by the liver and kidneys.

Details

items	specifications	results
appearance	white or almost white powder	comlies
solubility	freely soluble in water, sparingly soluble in methylene chloride, slightly soluble in methanol.	complies
identification	a) infrared absorption spectrophtometry comaprison: granisetron hydrochloride crs b) it gives reaction (a) of chloride	complies
a) solution s	concordant with r.s	complies
b) appearance of solution	concordant with r.s	complies
c) ph	4.0 to 6.5	4.6
d) impurity e	<0.5%	complies
related substance	total <1.0%	0.20%
	impurity a ≤1.0%	0.02%
	impurity b ≤0.5%	0.02%
	impurity c ≤0.2%	0.02%
	impurity d ≤0.1%	0.02%
	any other impurity≤0.1%	0.02%
	total ≤1.0%	0.01%
heavy metal	≤10ppm	<10ppm
sulphated ash	<0.1%	0.06%
loss on drying	<0.5%	<0.1%
residual solvents	methanol<0.3%	0.01%
bacterialendotoxins	<0.05eu/mg	<0.05eu/mg
assay	97%~102%	100.60%
conclusion	the results comply with the requirement of the ep7