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HENAN SUNLAKE ENTERPRISE CORPORATIONHot sale! Cas.no:78628-80-5 C21H26ClN Terbinafine Hydrochloride//file1.lookchem.com/cas/reactions/2021/05/27/5660449.png
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Hot sale! Cas.no:78628-80-5 C21H26ClN Terbinafine Hydrochloride CAS NO.78628-80-5

Min.Order Quantity:
10 Gram
Purity:
98% purity
Port:
Any Chinese main ports
Payment Terms:
L/C,T/T,MoneyGram,Other

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  • White powder 78628-80-5
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  • ProName: Hot sale! Cas.no:78628-80-5 C21H26ClN ...
  • CasNo: 78628-80-5
  • Molecular Formula: C21H26ClN
  • Appearance: white crystalline powder
  • Application: 78628-80-5
  • DeliveryTime: Within 7 working days since received y...
  • PackAge: 1g;5g;10g;25g;50g;100g;500g;1KG;5KG,25...
  • Port: Any Chinese main ports
  • ProductionCapacity: 20 Kilogram/Month
  • Purity: 98% purity
  • Storage: Under room tempearture condition .
  • Transportation: BY SEA/BY AIR /BY COURIER
  • LimitNum: 10 Gram
  • Certification: ISO/9001
  • Grade Standard: TEC

Superiority

hot sale! cas.no:

（1）high quality from own laboratory

（2）competitive price in china market.
（3）mature technical support
（4）fast delivery and shipping.

（5）we can help our regular clients to suggest some vials factories which produce different size vials(2ml, 5ml, 7ml, 10ml, 20ml...)

Details

terbinafine hydrochloride basic information
dermatologist broad-spectrum antifungal drugs pharmacokinetics indications usage and dosage chemical properties usage
product name: terbinafine hydrochloride
synonyms: (e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethylaminehydroc;lamosil;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmon;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmonohydrochloride;terbinafine hcl;n-[(2e)-6,6-dimethyl-2-hepten-4-ynyl]-n-methyl-1-naphthalenemethanamine;trans-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthylmethylamine hydrochloride;(e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine monohydrochloride
cas: 78628-80-5
mf: c21h26cln
mw: 327.89
einecs: 245-385-8
product categories: antifungal;apis;acetylenes;antifungals for research and experimental use;biochemistry;functionalized acetylenes;amines;aromatics;intermediates & fine chemicals;pharmaceuticals;terbinafine;lamisil
mol file: 78628-80-5.mol
terbinafine hydrochloride structure
terbinafine hydrochloride chemical properties
mp 204-208°c
storage temp. -20°c freezer
merck 9156
cas database reference 78628-80-5(cas database reference)
safety information
hazard codes xi,n
risk statements 36/37/38-50/53
safety statements 26-36/37/39-61-60
ridadr un 3077 9/pg 3
rtecs qj8600100
msds information
terbinafine hydrochloride usage and synthesis
dermatologist broad-spectrum antifungal drugs terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. it is developed by swiss novartis in the 1980 s, and appeared in the market of uk for the first time in 1991. approved by fda of the united states for otc drugs in 1996, and appeared in the market of the united states in the same year. at present, the drug is been sold in more than 90 countries of the word. it can specificity trouble the late biological decomposition of fungus sterol, selectively inhibit the activity of fungal squalene ring oxidase, and inhibit the squalene epoxidation in the formation of ungal cell membrane, thus to kill or inhibit the active of the fungus. suitable for treatment of candidiasis skin, such as tinea manuum, tinea, tinea, ringworm of the body, tinea versicolor, it is also the best medicine for the treatment of onychomycosis.
terbinafine hydrochloride entered the the first batch of country announced otc directory in 2000. this product belongs to antifungal drugs. it has strong effect on shallow fungal infection, and can cure most of the fungal skin diseases through external use.
pharmacokinetics according to reports in the literatures, after 250 mg of terbinafine hydrochloride been taken orally, it reaches peak plasma concentration of 0.97 m ug/ml within 2 hours. the absorption half-life is 0.8 hours, spread half-life is 4.6 hours, the degree of biological application is slightly affected by eating, but not used for dose adjustments. the combination rate of drugs and plasma protein is 99%, and can quickly disperse and concentrate in the lipophilic corneous layer through the dermis. terbinafine hydrochloride can be spread in the skin, therefore, a very high concentration can be reached in the hair follicle, hair and skin layers of fat, and it can enter in the deck in the last few weeks of healing. the metabolites after the bioconversion have no antifungal activity, then discharged through urine. the half-life is 17 hours, no accumulation in the body, and its steady blood drug concentration is not affected by age. but the alleviation rate can reduce for people with liver and kidney disorders, thus triggers blood drug concentration decreasing.
indications 1.skin, hair and nail infection caused by btrichophyta (white hair versicolor bacterium, trichophyton mentagrophytes, trichophyton verrucosum, trichophyton tonsurans and trichophyton violaceum, etc.), microsporum canis, epidermophyton floccosum, ect.
2.skin yeast infections caused by all kinds of tinea disease (ringworm of the body, tinea, tinea manus and tinea capitis, etc.) and candida (candida albicans, etc.).
3.onychomycosis (nail fungus infection) caused by molds.
usage and dosage local external use: apply adequate amount to the affected area and its surrounding, 1-2 times a day. ringworm of the body, 2-4 weeks, tinea of feet and hands, tinea versicolor, 4 to 6 weeks.
oral: 0.25 grams each time for adult, once per day, period of treatment is as follows:
skin infection treatment: tinea of feet and hands [toe (means) and plantar]: 2 ~ 6 weeks; ringworm of the body, tinea, 2 ~ 4 weeks.
skin candidiasis: 2 ~ 4 weeks. normal skin appearance and loss of infection can only be visible in a few weeks for curing.
hair and scalp infection treatment: tinea capitis: 4 weeks, tinea capitis most happen in children.
onychomycosis: the most treatment course of patients is 6 weeks to three months. young patients with normal growth can shorten the treatment course, and less than 3 months of treatment may be enough in addition to the thumb (foot) armour.
in other cases, the treatment is usually 3 months. some patients, especially whose thumb (toe) infected, may take 6 months or longer. the treatment may take more than 3 months if the nail grew slowly in the first week. in healing of mycology and stopping for a few months after treatment, the continuous improvement of nail appearance then completely normal can be seen, this is because that the healthy tissue growth needs time.
chemical properties white crystalline powder. melting point is 204-208 oc.
usage terbinafine hydrochloride is a kind of broad-spectrum dermatologist allyl amine antifungal drugs. it has a significant effect on all kinds of tinea diseases , including fungus, trichophyton, ringworm of the body, tinea, tinea versicolor and onychomycosis caused by dermophyte. it can also be used for bronchial asthma, asthmatic bronchitis and emphysema, etc.
this information is edited by chemicalbook xiao nan.
chemical properties crystalline powder
usage an orally active, antimycotic allylamine related to naftifine. a specfic inhibitor of squalene epoxidase, a key enzyme in fungal ergosterol biosynthesis. antifungal.
terbinafine hydrochloride preparation products and raw materials
preparation products terbinafine hydrochloride

company information :

hennan sunlake enterprise corporation is located in henan province , the central plain of china , which enjoys favorable geogeaphical position and convenient transportion, the com[any was established in june. 1998 , until now having more than 18 years experience in manufacturing & exporting chemical raw material .

sunlake is a professional manufacturer engaged in producing and selling chemicals,including organic & inorganic chemicals , pigments & dyestuffs , water treatment chemicals , food & feed additives and others . these products have been being well exported to europe , southeast asia , the middle east , africa , south america and some other countries and areas.

1. iso 9001 approved, gmp producing standard,proffesional qa system, our quality is guaranteed.

2. facotory direct sale, most comptive price ensured;

3. audited supplier on lookchem, no trick, no scam!

4. enough stock can make sure safe delivery.

5. complete before and after sale service, welcome your questions and glad to help.

welcome to china ,welcome to visit us . hope we can have a negotation with face to face. thank you very much .


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