Lovastatin CAS NO.75330-75-5

Min.Order Quantity:: 100 Metric Ton

Purity:: 98%min

Port:: QINGDAO CHINA

Payment Terms:: L/C,T/T,MoneyGram,Other

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75330-75-5
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Quick Details

ProName: Lovastatin
CasNo: 75330-75-5
Molecular Formula: C24H36O5
Appearance: red rice powder
Application: 1. Functional red yeast rice for heath...
DeliveryTime: Within 3-7 days after receipt of your ...
PackAge: As customer request
Port: QINGDAO CHINA
ProductionCapacity: 100 Metric Ton/Day
Purity: 98%min
Storage: Store in a cool,dry place and keep awa...
Transportation: Common products:Sea/Air/Courier Dange...
LimitNum: 100 Metric Ton

Superiority

triumph has the complete production of g- kg - mt service chain,we can make the new technology into productivity quickly in the research and development of new products.
main service
1.own made fine chemical products
2.out sourcing and quality controlling service in china
3. com for chemical synthesis
4.lab custom synthesis of api and intermadiates

quality assurance

1. nmr，hplc and coa can be supplied
2. free sample for testing

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Details

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lovastatin basic information

a cholesterol lowering agent

product name:	lovastatin
synonyms:	)ethyl]-1-naphthalenylester;[1s-[1alpha(r),3alpha,7beta,8beta(2s,4s),8abeta]]-2-methylbutanoicacid1,2,;1,2,6,7,8,8a-hexahydro-beta,delta-dihydroxy-2,6-dimethyl-8-(2-methyl-1-oxobuty;2-methyl-,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-(2-(tetrahydro-butanoicaci;3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl;3r,7s,8s,8ar)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[2r,4r)-tetrahydro-(1;4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl)-1-naphthalenylester,(1s-(1-alpha-(r),3;4-hydroxy-6-oxo-2h-pyran-2-yl]ethyl]-1-naphthalenyl(s)-2-methyl-butyrate
cas:	75330-75-5
mf:	c24h36o5
mw:	404.54
einecs:
product categories:	antibiotics;apis;intermediates & fine chemicals;pharmaceuticals;api's;hmg-coa reductase;chiral reagents;heterocycles;inhibitor;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from chinese medicinal herbs (tcm).;standardized herbal extract;isotopically labeled pharmaceutical reference standard;rythymol;antibiotic;cardiovascular apis
mol file:	75330-75-5.mol

lovastatin chemical properties

mp	175°c
refractive index	320 ° (c=0.5, ch3cn)
storage temp.	2-8°c
water solubility	0.0004 mg/ml at 25 ºc
merck	5586
cas database reference	75330-75-5(cas database reference)
epa substance registry system	butanoic acid, 2-methyl-, (1s,3r,7s,8s,8ar)-1,2,3,7, 8,8a-hexahydro-3,7-dimethyl- 8-[2-[(2r,4r)-tetrahydro- 4-hydroxy-6-oxo-2h-pyran- 2-yl]ethyl]-1-naphthalenyl ester, (2s)-(75330-75-5)

safety information

hazard codes	xi
risk statements	36/37/38
safety statements	22-24/25-36/37/39-26
ridadr	3077
wgk germany	3
rtecs	ek7907000
hazardclass	9
packinggroup	iii
hazardous substances data	75330-75-5(hazardous substances data)

msds information

provider	language
1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2h-pyran-2-yl)ethyl]-1-naphthalenyl 2-methylbutanoate	english
sigmaaldrich	english

lovastatin usage and synthesis

a cholesterol lowering agent	lovastatin is a cholesterol lowering agent isolated from a strain of aspergillus terreus. lovastatin is a white, nonhygroscopic crystalline powder that is insoluble in water and sparingly soluble in ethanol, methanol, and acetonitrile. after oral ingestion, lovastatin, which is an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. this is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a (hmg-coa) reductase. this enzyme catalyzes the conversion of hmg-coa to mevalonate, which is an early and rate limiting step in the biosynthesis of cholesterol.
chemical properties	white solid
usage	antiarrhythmic
usage	lovastatin (mevinolin) is a metabolite first isolated from monascus ruber and later found in several other fungal species. lovastatin is a potent inhibitor of hmg-coa. hmg-coa reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. lovastatin was developed as a drug as a hypolipemic agent.
usage	anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase inhibitor
usage	an antihypercholesterolemic agent. a fungal metabolite, which is a potent inhibitor of hmg-coa reductase
biological activity	potent, competitive inhibitor of hmg-coa reductase (k i = 0.6 nm) therefore decreases cholesterol biosynthesis, in vitro and in vivo . decreases cdk2, 4, 6 and cyclin e levels and induces g1 arrest and apoptosis in tumor cell lines in vitro .