USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $9.00-99.00 / Kilogram
USD $1.00-1.00 / Kilogram
mithramycin a basic information |
product name: | mithramycin a |
synonyms: | aureolic acid;methramycin a;mithracin;mithramycin;mithramycin a;mithramycin a, streptomyces plicatus;plicamycin;(2s-alpha,3beta(1r*,3r*4s*)))-droxy-7-methyl |
cas: | 18378-89-7 |
mf: | c52h76o24 |
mw: | 1085.15 |
einecs: | 232-455-8 |
product categories: | antibiotics;antitumour;antibiotic |
mol file: | 18378-89-7.mol |
mithramycin a chemical properties |
melting point | 180-183 °c |
storage temp. | 2-8°c |
merck | 13,7619 |
safety information |
hazard codes | xn,t+ |
risk statements | 22-26/27/28 |
safety statements | 45-38-36/37/39-28a-22 |
ridadr | 3249 |
wgk germany | 3 |
rtecs | pz2800000 |
f | 10 |
hazardclass | 6.1(b) |
packinggroup | iii |
mithramycin a usage and synthesis |
chemical properties | yellow powder |
usage | transcription inhibitor |
usage | mithramycin was the first of the aureolic acid class of antitumour antibiotics, isolated from streptomyces. mithramycin inhibits transcription and protein synthesis by non-covalent binding with g-c-rich duplex dna in the presence of magnesium and zinc ions. mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts. |
usage | mithramycin a was the first of the aureolic acid class of antitumor antibiotics, isolated from streptomyces. mithramycin inhibits transcription and protein synthesis by non-covalent binding with g-c-rich duplex dna in the presence of magnesium and zinc ions. mithramycin also induces differentiation of leukemic cells accompanied by an early decrease in c-myc expression, and selectively inhibits collagen-1 gene expression in human fibroblasts. |
biological activity | anticancer antibiotic that selectively binds to g-c-rich dna in the presence of mg 2+ or zn 2+ , inhibiting rna and dna polymerase action. inhibits c-myc expression and induces myeloid differentiation of hl-60 promyelocytic leukemia cells. |
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