4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile basic information
product name: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile
synonyms: 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile;etravirine;etravirine(tmc-125);r 165335;tmc 125;4-(6-amino-5-bromo-2-(4-cyanobenzyl)pyrimidin-4-yloxy)-3,5-dimethylbenzonitrile, etravirine;4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl -;4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile/etravirine
cas: 269055-15-4
mf: c20h15brn6o
mw: 435.284
einecs:
product categories: all inhibitors;inhibitors;intermediates & fine chemicals;non-nucleoside reverse transcriptase;pharmaceuticals;other apis
mol file: 269055-15-4.mol
4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile structure
4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile chemical properties
melting point .265°c (dec.)
storage temp. -20°c freezer
safety information
msds information
4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile usage and synthesis
chemical properties white to off-white solid
uses a novel hiv reverse transcriptase inhibitor useful in treatment of hiv infection
uses etravirine (tmc125) is a non-nucleoside reverse transcriptase inhibitor (nnrti) used for the treatment of hiv.
definition chebi: an aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. nnrti of hiv-1, binds directl to rt and blocks rna-dependent and dna-dependent dna polymerase activities
4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3, 5 –dimethylbenzonitrile preparation products and raw materials