cortisone basic information
product name: cortisone
synonyms: 17,21-dihydroxy-4-pregnene-3,11,20-trione;17,21-dihydroxypregn-4-ene-3,11,20-trione;20-trione,17,21-dihydroxy-pregn-4-ene-11;adrenalex;adreson;andreson;corlin;cortadren
cas: 53-06-5
mf: c21h28o5
mw: 360.44
einecs: 200-162-4
product categories: steroids;biochemistry;hydroxyketosteroids;intermediates & fine chemicals;pharmaceuticals;intracellular receptor;inhibitors
mol file: 53-06-5.mol
cortisone structure
cortisone chemical properties
melting point 223-228 °c (dec.)(lit.)
alpha d25 +209° (c = 1.2 in 95% alcohol); 25546 +269° (c = 0.125 in benzene); 25546 +248° (c = 0.1 to 0.2 in alcohol)
density 1.28±0.1 g/cm3 (20 ºc 760 torr)
refractive index 210 ° (c=1, etoh)
fp 9℃
storage temp. -20°c freezer
merck 2539
cas database reference 53-06-5(cas database reference)
safety information
hazard codes f,t,xn
risk statements 11-23/24/25-39/23/24/25-63
safety statements 22-24/25-45-36/37-16-7
ridadr un1230 - class 3 - pg 2 - methanol, solution
wgk germany 3
rtecs gm9020000
f 18
msds information
provider language
sigmaaldrich english
cortisone usage and synthesis
chemical properties off-white crystalline powder
uses glucocorticoid, anti-inflammatory agent
uses antiinflammatory, glucocorticoid
uses anticoagulant
definition chebi: a c21-steroid that is pregn-4-ene substituted by hydroxy groups at positions 17 and 21 and oxo group at positions 3, 11 and 20.
cortisone preparation products and raw materials
preparation products cortisone acetate
raw materials hydrogen peroxide-->chromic acid -->16-dehydropregnenolone acetate-->16a,17a-epoxyprogesterone