product name: retapamulin
synonyms: retapamulin;rebapamulin;sb-275833;retapamulin (sb-275833);(3as,4r,5s,6s,8r,9r,9ar,10r)-2-(exo-8-methyl-8-azabicyclo[3.2.1]octan-3-ylsulfanyl)acetic acid 5-hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinylperhydro-3a,9-propanocyclopentacycloocten-8-yl ester;retapamulin api;tetapamulin;(1s,2r,3s,4s,6r,7r,8r,14r)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.0^{1,8}]tetradecan-6-yl 2-{[(1r,3s,5s)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]sulfanyl}acetate
cas: 224452-66-8
mf: c30h47no4s
mw: 517.77
einecs:
product categories: api, antibiotics;inhibitors
mol file: 224452-66-8.mol
retapamulin structure
retapamulin chemical properties
cas database reference 224452-66-8(cas database reference)
safety information
msds information
retapamulin usage and synthesis
uses retapamulin is a topical antibiotic, which binds to both e. coli and s. aureus ribosomes with similar potencies with kd of 3 nm
uses retapamulin is a semi-synthetic pleuormutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. this enables formulation as a stable hydrochloride salt. retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain v of 23s rrna.
uses a broad spectrum antibiotic with no cross resistance to existing classes
uses retapamulin is a semi-synthetic pleuromutilin prepared by reacting pleuromutilin tosylate with tropine-3-thiol to give a more hydrophobic analogue with a tertiary amine. this enables formulation as a stable hydrochloride salt. retapamulin is a broad spectrum antibiotic with no cross resistance to existing antibiotic classes, and is the first pleuromutilin approved for human use. like all the pleuromutilins, retapamulin inhibits protein synthesis by binding to domain v of 23s rrna.