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ruxolitinib phosphate basic information
product name: ruxolitinib phosphate
synonyms: (betar)-beta-cyclopentyl-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazole-1-propanenitrile phosphate;incb 018424;ruxolitinib, phosphate salt;ruxolitinib, phosphate;(βr)-β-cyclopentyl-4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazole-1-propanenitrile phosphate;incb 018424(ruxolitinib phosphate);incb 018424 (phosphate);incb018424 (phosphate)
cas: 1092939-17-7
mf: c17h18n6.h3po4
mw: 404.360201
einecs:
product categories: intracellular signaling.;antineoplastic;inhibitors
mol file: 1092939-17-7.mol
ruxolitinib phosphate usage and synthesis
uses the phosphate salt of ruxolitinib (r702000). ruxolitinib is a selective janus tyrosine kinase (jak1 and jak2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
definition chebi: a phosphate salt obtained by reaction ruxolitinib with one equivalent of phosphoric acid. used for the treatment of patients with intermediate or high-risk myelofibrosis, including primary myelofibrosis, post-polycythemia vera myelofibrosis and post-essent al thrombocythemia myelofibrosis.