TIANFUCHEM--2581-34-2--High purity 3-Methyl-4-nitrophenol factory price CAS NO.2581-34-2

3-methyl-4-nitrophenol

english synonyms: 3-methyl-4-nitro-pheno; 4-nitro-1-hydroxy-3-methylbenzene; 4-nitro- -methyl-4-nitrophenol; m-cresol, 4-nitro-; phenol,

cas number: 2581-34-2

molecular formula: c7h7no3

molecular weight: 153.14

einecs no. 219-952-5

related categories: aromatic phenols; phenoles and thiophenoles; pesticide intermediates; pesticide intermediates; organophosphorus pesticides; other oxygenates; standards; pharmaceutical intermediates; reagents and supplements

mol file: 2581-34-2.mol

4-nitro-m-cresol

4-nitro-m-cresol properties

melting point 125-130 ° c (lit.)

boiling point 200 ℃ (decomposition)

flash point of 110 ℃

soluble in water (1.34g / l).

brn 1868105

cas database 2581-34-2 (cas database reference)

nist chemical information 4-nitro-5-methylphenol (2581-34-2)

epa chemical information phenol, 3-methyl-4-nitro- (2581-34-2)

use of 4-nitro-m-cresol and synthesis method

chemical acicular or columnar yellow crystals. in the air, the light does not change color. very soluble in ethanol, ether, chloroform and benzene. hard to dissolve in cold water.

use as a pharmaceutical intermediates

nitro-m-cresol, also known as 3-methyl-4-nitrophenol (abbreviated as 4-nitro), is an intermediate of fenitrothion.

uses a wide range of uses, mainly for the manufacture of pesticides fenitrothion (an efficient, low toxicity, low residual excellent organophosphate insecticide).

production methods to m-cresol as raw material, available nitrosation oxidation or direct nitrification preparation. 1. hydrochloride nitrosation oxidation of m-cresol with 15% hydrochloric acid, sodium nitrite, sodium hydroxide at a reaction temperature (0 ± 3) ℃ under reaction to obtain a nitroso compound. then in 38% nitric acid at (40 ± 2) ℃ oxidation, that is, too. yield 87%. 2. one-step nitric acid will be m-cresol at -5 ~ 0 ° c 20% nitric acid and 40% sodium nitrite solution, stirred for 10 minutes, warmed to 30 ℃ and incubated 2h, that is, too. yield 99%. there is also a method called hydroxyl protection nitrification.

production methods of nitro-m-cresol preparation nitrosation oxidation and one-step nitration. because of one-step nitration method consumption of larger amount of phenol, higher cost, so the industrial nitrosation oxidation method. the reaction equation shown in the figure

in the nitrosation kettle pre-prepared dilute nitric acid added in a strong mixing and low temperature drop cresol and sodium nitrite mixture. after the addition of low temperature to maintain a certain reaction time, the material into the oxidation reactor slowly warming oxidation. with na2co3 liquid to absorb a large amount of release of nox, when the temperature inside the oxidation reactor up to 47 ℃, the release of nox almost clean, cooled to below 25 ℃, centrifuged into the centrifuge to give crude 4-nitrate. after the metered analysis was added to the refining kettle, heated to dissolve by toluene, crystallized at low temperature, and then separated in an explosion-proof centrifuge to obtain fine 4-nitro.