Preparation of a carboxymethylcellulose-iron composite for uptake of Atorvastatin (cas 134523-00-5) in water

Add time:07/31/2019    Source:sciencedirect.com

Many water bodies are being contaminated by Atorvastatin (cas 134523-00-5), which has certain side effects and problems on healthy individuals through contaminated water. For this purpose, effective and selective carboxymethylcellulose macromolecule iron composite nanoparticles were synthesized by green methods, characterized and used for uptake of atorvastatin drug residue from water. Atorvastatin in water was analyzed by HPLC using Aqua C28 (250 mm × 46 mm id) column and buffer-ACN (35:65, v/v) as eluent. The maximum elimination of atorvastatin was 80% with 40 μg L−1 concentration; 40 min agitated time, 5.0 pH, 1.0 g L−1 dose and 298 K temp. The removal data obeyed Freundlich, Langmuir, Dubinin-Radushkevich and Temkin models. The values of free energy were −8.79, −8.73 and −8.65 kJ mol−1 at 20.0, 25.0 and 30.0 °C temperatures. Enthalpy value was −14.16 kJ mol−1; showing exothermic removal. Entropy was −18.74 × 10−3 kJ mol−1 K; presenting decrease in entropy in the process. The kinetics modeling showed pseudo-first-order and liquid film diffusion mechanisms of removal. The removal technology was quick, conservation pleasant and lucrative. It is because of it capability with little dose and interaction time. Hence, the reported technology is practical for the exclusion of atorvastatin in water resource.

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